I-Corps: Analytical Chemistry for Everyone Using CMV

在爆炸物检测和枪击残留物检测领域的研究表明，该装置具有很高的灵敏度，适用于收集各种应用中的低浓度挥发物。拟议的技术(毛细挥发物微萃取器，CMV)被开发用于法医相关化合物的检测，包括毒品、爆炸物残留物、易燃液体残留物和枪击残留物。CMV是一种廉价的方式，可以为每个人带来复杂的分析化学能力。CMV的潜在应用包括一个主动学习工具包，向初中生传授对环境中少量挥发物进行采样和检测的科学知识，并将包括一个连接用户并提供世界各地空气质量数据的社交网络。环境应用包括使用CMV对我们呼吸的空气中疑似含有危险化学物质(包括致癌物质)的空气进行采样。生物医学应用包括首次使用CMV对人体呼吸进行采样，以检测消费者工具包中的疾病标志物。CMV装置由涂有吸着剂的玻璃纤维组成，具有超高的表面积，当空气通过该装置进行动态采样时，可以吸收挥发物。CMV体积小(2厘米x 2毫米)，价格低廉，非常容易用来在不到1分钟的时间内从空气中采样和预浓缩亚微克数量的挥发性有机化合物(VOCs)。CMV可以很容易地与气相色谱质谱计连接，分析结果的解释可以针对特定的应用进行标准化，包括室内空气质量监测、法医分析、化学暴露监测以及用于医疗诊断和疾病监测的呼气生物标志物的分析。CMV的商业优势包括对环境空气或呼气进行一次性、简单和廉价的采样，在这些环境空气或呼气中存在非常低水平的目标化合物。CMV还将作为研究实验室的消耗品上市，供科学家进行空气采样。将开发供公众使用的具体应用程序，包括分析服务和结果解释，以使每个对进行空气采样感兴趣的人都更容易获得分析化学。该团队计划推出非常具体的应用测试套件，用于监测室内空气中的挥发性化合物，作为教授化学和人体呼气空气测试的教育工具。

The research in the areas of explosives detection and gunshot residue detection has demonstrated a high sensitivity of the device making it applicable for the collection of low concentration volatiles across a range of applications. The proposed technology (Capillary Microextractor of Volatiles, CMV) was developed for the detection of forensic related compounds including drugs, explosive residues, ignitable liquid residues and gunshot residues. CMV is an inexpensive way to bring sophisticated analytical chemistry capabilities to everyone. Potential applications of the CMV include an active learning toolkit to teach middle and high-school students the science of sampling and detection of small quantities of volatiles in our environment and will include a social network that connects users and provides air quality data around the world. Environmental applications include the use of CMV to sample air suspected of containing hazardous chemicals in the air we breathe, including carcinogens. Biomedical applications include the use of CMV to sample human breath to detect disease markers in a consumer kit, for the first time. The CMV device is composed of sorbent-coated glass microfibers with an ultra-high surface area that can absorb volatiles when air is dynamically sampled through the device. The CMV is small (2cm x 2mm), inexpensive and very easy to use to sample and pre-concentrate sub-ng quantities of volatile organic compounds (VOCs) from air in less than 1 minute. The CMV is easily coupled to a gas chromatograph mass spectrometer and the interpretation of the analytical results can be standardized for specific applications including indoor air quality monitoring, forensic analysis, monitoring of chemical exposure and analysis of breath biomarkers for medical diagnosis and disease monitoring. The commercial advantages of CMV include single-use, simple and inexpensive sampling of ambient air or breath, where very low levels of target compounds are present. The CMV will also be marketed as a research laboratory consumable to scientists for air sampling. Specific applications will be developed for use by the general public that include analytical services and interpretation of results in order to make analytical chemistry more accessible to everyone interested in conducting air sampling. This team plans to market very specific application test kits for monitoring volatile compounds in indoor air, as educational tools to teach chemistry and for human breath air testing.