Allosteric modulators as novel probes of G-Protein coupled receptor function

这项研究将为哺乳动物基因组中最大的蛋白质家族之一的功能提供新的机制理解，也是关于药物靶点的最重要的家族之一。因此，所获得的洞察力与药物发现直接相关。新型G蛋白偶联受体(GPCR)变构增强剂的发现不仅将带来潜在的新的治疗药物，而且可以显著增加其他专注于GPCR结构生物学的国家研究工作的价值。

This research will provide novel mechanistic understanding on the function of one of the largest protein families in the mammalian genome, and the most important family with respect to drug targets. The insights gained thus have direct relevance to drug discovery. The discovery of novel G protein-coupled receptor (GPCR) allosteric enhancers will not only lead to potentially new therapeutic agents, but can significantly value-add to other national research efforts focusing on GPCR structural biology.