PFI:AIR - TT: Wireless implantable pressure sensor for continuous monitoring of chronic disorders

这个PFI: AIR技术翻译项目专注于翻译第一个用于生理监测的无线、微制造、基于微泡的压力传感器，以填补目前慢性、植入式诊断传感器的技术空白。转换后的技术可为患有慢性（通常是终身）疾病的患者提供可靠的实时压力记录，这些疾病的风险因素或指标是血压升高，并且无需笨重的外部诊断工具。微泡压力传感器具有以下独特的特点：生物相容性结构，占地面积小（小于0.1平方英尺）。)，无线控制和电源，以及微泡转导机制。微泡转导机制规避了机械疲劳和生物污垢等失效模式，这些失效模式困扰着依赖弹性膜挠曲的传感器。这些特点提供了一种不显眼、可靠的植入物，与目前最先进的生理压力监测相比，在慢性体内监测中有更大的应用。该项目将产生一个工作原型压力传感器和关键数据，以降低正在进行的开发风险。该项目通过将用于电力和遥测的无线电路集成到现有的微泡传感器原型中，并通过生成长期准确性、精度和可重复性的关键特性数据，作为将技术转化为商业部署的必要步骤，解决了当前的技术差距。研究生和本科生的研究人员将完成器件电子和封装，并通过彻底的台式测试校准原型压力传感器。此外，参与该项目的所有人员都将受益于我们的I-Corps节点和Coulter研讨会系列提供的转化教育计划，这些计划将使他们接触到客户发现，客户访谈，精益创业方法，医疗设备商业化以及监管和报销策略。该团队正在与洛杉矶儿童医院的神经外科医生合作；他们将为脑积水生物医学技术的设计和应用提供指导。该团队还将利用行业联系和技术商业化计划，为商业化、制造和融资提供指导和培训，因为它们与将技术转化为具有竞争力的商业现实的潜力有关。该项目的潜在经济和社会影响包括提高美国在生物医学传感技术方面的竞争力，以及通过新的临床压力传感器提高医疗质量和降低医疗成本，为慢性患者提供数据驱动的诊断和及时的医疗干预。

This PFI: AIR Technology Translation project focuses on translating the first wireless, microfabricated, microbubble-based pressure sensor for physiological monitoring to fill the current technology gap in chronic, implantable diagnostic sensors. The translated technology offers reliable pressure recordings in real-time for patients suffering from chronic, often life-long medical conditions for which elevated pressure is a risk factor or indicator, and removes the need for bulky exterior diagnostic tools. The microbubble pressure sensor has the following unique features: biocompatible construction, small footprint (less than 0.1 sq. mm.), wireless control and power, and a microbubble transduction mechanism. The microbubble transduction mechanism circumvents failures modes such as mechanical fatigue and biofouling, which plague sensors that rely on deflection in elastic membranes. These features provide for an unobtrusive, reliable implant, with greater application to chronic in vivo monitoring compared to current state-of-the-art in physiological pressure monitoring. The project will result in a working prototype pressure sensor and critical data to de-risk on-going development. This project addresses current technology gaps by integrating wireless circuitry for power and telemetry into the existing prototype microbubble transducer and by generating critical characterization data on long term accuracy, precision and repeatability, as necessary steps for translating the technology toward commercial deployment. Graduate and undergraduate researchers will work to finalize device electronics and packaging and calibrate the prototype pressure sensor with thorough benchtop testing. In addition, all personnel involved in this project, will benefit from translational education programs offered by our I-Corps node and Coulter workshop series that will expose them to customer discovery, customer interviews, Lean Startup methodology, medical device commercialization, and regulatory and reimbursement strategy. The team is collaborating with neurosurgeons at the Children's Hospital Los Angeles; they will provide guidance in design and deployment of biomedical technologies for hydrocephalus. The team will also leverage industry connections and technology commercialization programs for guidance and training on commercialization, manufacturing, and financing as they pertain to the potential to translate the technology into a competitive commercial reality. The potential economic and societal impact of this project include greater US competitiveness in biomedical sensing technology, and the improvements in healthcare quality and reductions in healthcare cost realized by new clinical pressure sensors, that offer data driven diagnostics and timely medical interventions for chronically suffering patients.