I-Corps: Noninvasive method for assessing cardiovascular stress arising from acute exposure to nanoparticles

由于现代技术使收集各种各样的大量数据变得极其便宜和容易，因此需要新的方法来分析这些信息，以使这类技术真正有用。特别是，价格实惠的便携式心电图（ECG）测量设备的出现，使收集和存储关于患者的详细信息成为可能。个人心血管系统。然而，未经训练的个人解释这些原始信息的能力有限，限制了这种技术的革命性医疗保健潜力。因此，要求与医生面对面的访问并没有减少，并且出现了许多关于医生存储、传输和监督这些信息的责任的伦理问题。在这个项目中，I-Corps团队概述了一项策略，通过将心血管健康的新指标纳入目前可用的便携式心电图测量设备，将这种技术提升到个性化的下一个水平。在数字时代，从大量数据中提取有意义信息的能力至关重要。该技术的核心是隔离心血管系统内的自由度，这些自由度控制着心脏对外部压力（包括污染物）的特定反应。通过所谓的“耐火储备”（RoR），实时测量心肌从单次收缩中恢复的物理能力，开启了对任意类型潜在污染物暴露进行非侵入性评估的大门。引入的度量的一个显著特征是它对低分辨率单导联心电测量设备的固有噪声缺乏敏感性。这种刚度使得所提出的耐火度度量在各种实际情况下成为分析心血管系统的理想方法。具体来说，拟议中的技术展示了它如何为医疗行业、关注职业或环境危害的公司以及庞大的健身行业带来回报。

As modern technology has made the collection of vast amounts of data of all kinds extremely cheap and easy, new approaches to analyzing such information are required for this type of technology to be truly useful. In particular, the advent of affordable and portable electrocardiogram (ECG) measurement devices has enabled collection and storage of hours of detailed information about patients? personal cardiovascular system. However, the untrained individual's limited ability to interpret this raw information limits the revolutionary healthcare potential of such technology. Consequently, there is no decrease in required face-to-face visits with a physician, and many ethical questions arise regarding storage, transmission and responsibility of the doctor to monitor such information. In this project, this I-Corps team outlines a strategy for taking such technology to the next level of personalization by incorporating a novel metric for cardiovascular health into currently available portable ECG measurement devices.The ability to extract meaningful information from a large set of data is of paramount importance in the digital age. At its core, the proposed technology isolates the degrees of freedom within the cardiovascular system that govern a particular aspect of the heart's response to external stresses including pollutants. By enabling real-time measurement of the cardiac muscle physical ability to recover from a single contraction through the so-called "reserve of refractoriness" (RoR), the door to non-invasive assessment of exposure to arbitrary types of potential pollutants is opened. A remarkable feature of introduced metric is its lack of sensitivity to the inherent noise in low-resolution, single-lead ECG measurement devices. Such a stiffness makes the proposed refractoriness metric an ideal method for analyzing the cardiovascular system in a variety of practical contexts. Specifically, the proposed technology demonstrates how it may be rewarding for the medical industry, companies with concern for occupational or environmental hazards, as well as for the vast fitness industry.