NSF/FDA SIR: Micro- and macro-scale validation of diffuse correlation spectroscopy for monitoring functional hemodynamics in the microvasculature of the cerebral cortex

PI: Fisher， jonathan提案号：1641133现有的监测方法存在技术上的限制，例如无法检测小血管的流量变化，以及实用上的限制，例如床边监测涉及的便携性和安全性问题。成本是当前临床诊断的另一个限制；小医院往往没有这种能力。漫射相关光谱（DCS）等经颅光学技术可以提供快速、实时的大脑活动监测，而成本只是其他方法的一小部分。PI将评估漫射相关光谱（DCS）作为监测脑血流实时变化的非侵入性光学方法。拟议的研究将与纽约医学院、科罗拉多大学、宾夕法尼亚大学和FDA的研究人员、教师和博士后合作。该建议包括由PI实施的精心设计的指导计划。该计划包括通过个人发展计划跟踪进度；非正式讨论，评估对指导计划的满意度，并跟踪职业目标的进展情况。该项目将提供关于可以使用低分辨率漫射相关光谱（DCS）技术查询的变化类型的信息。直接比较高分辨率技术将提供必要的信息敏感性和特异性的DCS。在监测期间使用刺激变化将提供可评估的血管种群的必要细节类型。在神经损伤或疾病的情况下，脑血流可用于告知医疗干预措施。

PI: Fisher, JonathanProposal Number: 1641133Existing monitoring methods have technological limitations, such as the inability to detect flow changes in small blood vessels, as well as practical ones, such as portability and safety issues involved in bedside monitoring. Cost is an additional limitation for current clinical diagnostics; small hospitals often do not have such capabilities. Transcranial optical techniques such as diffuse correlation spectroscopy (DCS) can provide rapid, real-time monitoring of brain activity for a fraction of the cost of other methods. The PI will evaluate diffuse correlation spectroscopy (DCS) as a noninvasive optical methods for monitoring real-time changes in cerebral blood flow. The proposed research will partner researchers, faculty and postdocs at the New York Medical College, the University of Colorado, the University of Pennsylvania, and the FDA. The proposal includes a well-designed mentoring plan to be implemented by the PI. The plan includes tracking progress through Individual Development Plans; informal discussions to assess satisfaction with the mentoring program' and tracking progress toward career goals.This project will provide information on the types of changes that can be interrogated using the low-resolution diffuse correlation spectroscopy (DCS) technique. Direct comparison to a high resolution technique will provide necessary information on sensitivity and specificity for DCS. The use of stimulated changes during monitoring will provide the types of necessary detail on the populations of blood vessels that can be assessed. Cerebral blood flow can be used to inform medical interventions in cases of neurological injury or disease.