SI2-SSI Collaborative Research: The SimCardio Open Ssource Multi-Physics Cardiac Modeling Package

心血管(CV)模拟已成为外科计划、器械设计、诊断和疾病机制基础研究的重要组成部分。该项目团队此前开发了SimVial(www.simcular.org)，这是目前唯一提供从医学图像数据分割到动脉和静脉中患者特定血流模拟和分析的完整管道的开源软件包。SimCardio开源项目将把SimVial的功能扩展和增强到心脏建模领域，提供第一个完全集成的心脏生理和功能计算机模型。这将帮助基础科学和医学研究人员对影响儿童和成人心脏功能的多种疾病进行计算机建模。这种计算机建模软件将使研究人员能够直接从医学成像数据建立心脏和血管解剖模型，这些模型可用于个性化治疗计划和医疗设备设计，最终为心血管疾病患者带来新的治疗方法。SimCardio项目将创建一个独特的开源软件包，用于多物理心脏建模和仿真。SimCardio将包括一个新的多物理有限元解算器，该解算器具有大变形流体-结构相互作用(FSI)的能力，以捕捉心室收缩和心脏瓣膜动力学、非线性和粘弹性材料模型、主动心脏收缩的心脏力学模型和电生理学。这将通过连接心血管流体和固体力学社区的可持续软件基础设施来促进。该项目将为高通量构建特定于患者的心脏和血管模型提供新的用户界面。SimCardio将扩大SimVial的适用范围，以解决心脏瓣膜、心力衰竭、心肌病、主动脉夹层、结构性先天性心脏病和医疗设备等问题。为了促进采用，该项目将公开提供附带的教育和培训材料，并维持一个可持续的软件生态系统，以增加用户社区，并确保持续提供和发展。

Cardiovascular (CV) simulations have become a crucial component of fundamental research in surgical planning, device design, diagnosis, and disease mechanisms. The project team has previously developed SimVascular (www.simvascular.org), which is currently the only open source software package providing a complete pipeline from medical image data segmentation to patient specific blood flow simulation and analysis in arteries and veins. The SimCardio open source project will extend and enhance the functionality of SimVascular to the realm of heart modeling, providing the first fully integrated computer model of cardiac physiology and function. This will help basic science and medical researchers perform computer modeling in numerous diseases affecting heart function in children and adults. This computer modeling software will enable researchers to build models of the heart and vascular anatomy directly from medical imaging data, which can be used for personalized treatment planning and medical device design, ultimately leading to new treatments for patients with cardiovascular disease. The SimCardio project will create a unique open source software package for multi-physics cardiac modeling and simulations. SimCardio will include a new multi-physics finite element solver with capabilities for large-deformation fluid-structure interaction (FSI) to capture ventricular contraction and heart valve dynamics, non-linear and visco-elastic material models, cardiac mechanics models of active heart contraction, and electrophysiology. This will be facilitated by sustainable software infrastructure bridging the cardiovascular fluid and solid mechanics communities. The project will provide a new user-interface for high-throughput construction of patient-specific cardiac and vascular models. SimCardio will broaden the applicability of SimVascular to problems including heart valves, heart failure, cardiomyopathy, aortic dissection, structural congenital heart defects and medical devices. To facilitate adoption, the project will publicly provide accompanying educational and training materials, and maintain a sustainable software ecosystem to increase the user community and ensure continued availability and evolution.