NSF-Simons Southeast Center for Mathematics and Biology

该奖项通过在佐治亚理工学院建立NSF-Simons东南数学和生物学中心(SCMB)来促进复杂生物系统的数学研究。SCMB是一个具有全国影响力的地区性中心，其明确的任务是将数学理论与生物系统数据联系起来。该中心的核心活动是在数学-生物学界面促进新的研究合作，集体关注于了解关键基因组到物候组接合点的新特性。与之相辅相成的是强有力的跨学科培训部分，重点是使受训人员能够在他们的研究事业取得进展时启动新的跨学科合作，并辅之以教育宣传和召集研究活动。通过这些方式，SCMB正在通过推动将这两个领域推向新领域的发现来应对在数学-生物界面建设研究能力的挑战。NSF-Simons东南数学和生物学中心认识到，多样化的数据来源需要不同的理论方法，从生物系统获得的新颖数据结构促进了数学增长。此外，该中心已确定其根本挑战是发展数学-生物学研究合作，以推动这两个学科的前沿。该中心围绕一系列由跨学科数学家和生物系统实验学家感兴趣的研究问题定义的种子项目构建，这些问题解决了遗传信息和表型特征之间出现的关键方面。参与的生物系统教员的研究兴趣从分子细胞生物学到行为动力学，他们为中心带来了大量的定量建模和计算分析专业知识。参与研究的数学家具有跨学科经验和许多共同的研究兴趣，包括在生物系统应用方面具有相当大潜力的基础领域。通过积极地匹配实验学家和数学家，SCMB正在催化新的数学-生物学合作。这些新颖的跨学科团队将指导学员，重点是建立互动专业知识。教育外展将通过启动数学-生物管道来建设劳动力能力，发起的活动将在东南部建立一个复杂生物系统数学的国家重心。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award promotes the mathematics of complex biosystems by establishing the NSF-Simons Southeast Center for Mathematics and Biology (SCMB) at the Georgia Institute of Technology. The SCMB is a regional center with national impact whose defining mission is connecting mathematical theory with biosystems data. The core Center activity is catalyzing new research collaborations at the mathematics-biology interface with a collective focus on understanding emergent properties at critical genome-to-phenome junctures. This is complemented by a strong interdisciplinary training component, with an emphasis on enabling trainees to initiate new transdisciplinary collaborations as they progress in their research careers, and is supplemented by educational outreach and convening research activities. In these ways, SCMB is addressing the challenge of building research capacity at the mathematics-biology interface by driving discoveries that propel both fields forward into new territory.The NSF-Simons Southeast Center for Mathematics and Biology recognizes that diverse sources of data require diverse theoretical approaches and that novel data structures acquired from biological systems spur mathematical growth. Moreover, the Center has identified its fundamental challenge as developing mathematics-biology research collaborations that advance the frontiers of both disciplines. The Center is structured around a collection of seed projects defined by research questions of interest to both interdisciplinary mathematicians and biosystems experimentalists that address critical aspects of emergence between genetic information and phenotypic traits. Participating biosystems faculty have research interests ranging from molecular cell biology to behavioral dynamics, and they bring substantial quantitative modeling and computational analysis expertise to the Center. Participating mathematicians have prior interdisciplinary experience and many research interests in common, including foundational areas with considerable untapped potential in biosystems applications. By actively matching experimentalists and mathematicians, SCMB is catalyzing new mathematics-biology collaborations. These novel interdisciplinary teams will mentor trainees with an emphasis on building interactional expertise. Educational outreach will build workforce capacity by priming the mathematics-biology pipeline, and convening activities will establish a national center of gravity in the Southeast for the mathematics of complex biosystems.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.