Lanthanide Complexes with Concurrent Metal-Centered Emission and Singlet Oxygen Generation

在这个由美国国家科学基金会化学分部化学结构、动态和机制B项目资助的项目中，内华达大学里诺分校的Ana de Bettencourt-Dias教授和她的研究小组正在制备能够以金属为中心发光的镧系离子复合物，同时能够产生单线态氧。他们的长期目标是开发能够同时用于成像和破坏病变组织的新系统。本项目处于有机合成、配位化学和光谱学的交叉领域。各个层次的学生都参与了这项研究，德·贝当古-迪亚斯教授在与不同群体的本科生和研究生合作方面有着良好的记录。作为她对研究生教育承诺的一部分，她将教授一门科学写作课程，这门课程对前几代研究生来说已经证明是有价值的。能够产生单线态氧的发光化合物对于需要细胞成像和细胞毒性的应用具有潜在的兴趣，例如光动力治疗，从而使癌症治疗能够同时成像癌细胞。镧系离子的发光能力已经得到了很好的证明，本文提出使用不同类型的配体，以萘酰亚胺、芘和噻吩-苯基-噻吩为基础，不仅可以敏化金属中心发光，还可以产生单线态氧。配体组成和所产生的配合物性质之间的关系将使用吸收、激发和发射光谱进行评估。基于咔唑的另一个配体家族，以其双光子吸收能力而闻名，将用于分离异电复合物并实现低能激发。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

In this project, funded by the Chemical Structure, Dynamic & Mechanisms B Program of the Chemistry Division of the National Science Foundation, Professor Ana de Bettencourt-Dias and her research group at the University of Nevada, Reno, are preparing lanthanide ion complexes capable of metal-centered light emission, while at the same time being able to generate singlet oxygen. Their long term goal is to develop new systems that can be used at the same time to image and destroy diseased tissues. This project lies at the interface of organic synthesis, coordination chemistry and spectroscopy. Students of all levels are involved in this research and Professor de Bettencourt-Dias has a track-record of working with a diverse group of undergraduate and graduate students. As part of her commitment to graduate education, she will teach a course in science writing, which has already proven valuable to previous generations of graduate students. Luminescent compounds capable of generating singlet oxygen are potentially interesting for applications requiring cell imaging and cell toxicity, such as photodynamic therapy, thus enabling cancer therapy with simultaneous imaging of the cancerous cells. The light emission ability of the lanthanide ions has been well documented, and here it is proposed to use different types of ligands, based on naphthalimide, pyrene and thiophene-phenyl-thiophene, to not only sensitize the metal-centered luminescence, but also to generate singlet oxygen. The relationships between ligand composition and resulting complex properties will be assessed using absorption, excitation and emission spectroscopy. An additional family of ligands, based on carbazole, which is known for its two-photon absorption capabilities, will be used to isolate heteroleptic complexes and enable low-energy excitation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.