FOR 2060: cGMP Signalling in Cell Growth and Survival

cGMP是一种细胞内信使分子，参与多种生理功能的调节，例如血管、心脏、神经元和感觉细胞。研究小组调查了cGMP信号系统的功能障碍如何促进心血管和神经系统退行性疾病的发展。目的是更好地了解cGMP的生理和病理生理作用和治疗潜力。调节细胞内cGMP水平的药物可能为治疗退行性疾病提供新的选择。

cGMP is an intracellular messenger molecule that is involved in the regulation of diverse physiological functions, for example, in blood vessels, the heart, neurons and sensory cells. The Research Unit investigates how a dysfunction of the cGMP signalling system contributes to the development of degenerative diseases of the cardiovascular and nervous system. The goal is a better understanding of the physiological and pathophysiological roles and therapeutic potential of cGMP. Drugs that modulate the intracellular cGMP level might provide new options to treat degenerative diseases.