PFI-RP: Brain-controlled Upper-Limb Robot-Assisted Rehabilitation Device for Stroke Survivors.

这个PFI项目更广泛的影响/商业潜力是，通过利用非侵入性脑接口提取患者信息的优势-S运动意图和运动功能受损和恢复的实时评估-来加速中风后脑控机器人康复的开发、疗效和使用，从而促进国民健康。在美国，中风是导致神经系统残疾的主要原因，每年约有795,000人中风。手臂瘫痪是致残的主要原因，因为它在日常生活活动(ADL)中造成了限制。大约80%的中风幸存者患有上肢瘫痪，其中只有18%的人在中风后一年内通过常规治疗获得了完全的运动恢复。因此，对受损肢体的康复对于改善ADLS和卒中后的生活质量是必不可少的，然而只有31%的卒中幸存者接受门诊康复。脑控机器人设备是吸引患者并提供中风幸存者康复所需的重复和密集练习的极佳候选者。我们创新的机器人康复解决方案将为治疗师提供更高的效率、更低的费用和新的传感功能，同时减少残疾的社会经济负担。拟议的项目解决了对可获得、安全和有效的中风康复设备的迫切需求，供诊所和家庭使用，用于可持续的长期治疗，到2021年，全球市场规模预计将达到310亿美元。不幸的是，目前的设备无法吸引患者，难以匹配他们的需求，使用和维护成本高昂，或者仅限于临床环境。我们的患者在回路系统解决方案包括我们的专利非侵入性脑机器人技术，该技术将用户的大脑活动转换为运动命令，以驱动有动力的、按需辅助的上肢机器人，以进行中风康复。绩效反馈将通过用户界面提供给患者和临床医生，并存储用于监控和诊断，该用户界面还用于提供任务和相关完成绩效的实时反馈。系统验证将在临床环境和家庭中进行。智能优势包括解决容错系统集成、低成本设备原型、可用性、共享控制、获取验证数据以及加快新型生物医学设备向患者转化的挑战。可交付的是一个可访问的、安全和有效的脑控治疗机器人系统，该系统是多功能的，具有实时自我监控、自我诊断和自我纠正的能力，并促进神经功能恢复。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this PFI project is to advance the national health by accelerating the development, efficacy and use of brain-controlled robotic rehabilitation after stroke by capitalizing on the benefits of non-invasive brain interfaces that extract information about the patient?s motor intent and the real-time assessment of impairment and recovery of motor function. Stroke is the leading cause of neurological disability in the United States with approximately 795,000 people suffering a stroke each year. Arm paresis is a primary cause of disability because of the limitations it creates in performing activities of daily living (ADL). Approximately 80% of all stroke survivors suffer from upper limb paresis and only 18% of these individuals gain full motor recovery with conventional treatments in the year following stroke. Thus, rehabilitation of the impaired limb is essential for improving ADLs and quality of life after stroke, yet only 31% of stroke survivors receive outpatient rehabilitation. Brain-controlled robotic devices are excellent candidates for engaging the patients and delivering the repetitive and intensive practice stroke survivors require for rehabilitation. Our innovative robotic rehabilitation solution will offer increased efficiency, lower expenses, and new sensing capabilities to the therapist while reducing the socioeconomic burden of disability. The proposed project addresses a pressing need for accessible, safe and effective stroke rehabilitation devices for in-clinic and at-home use for sustainable long-term therapy, a global market size expected to reach $31B by 2021. Unfortunately, current devices fail to engage the patients, are hard to match to their needs, are costly to use and maintain, or are limited to clinical settings. Our patient-in-the-loop system solution consists of our patented noninvasive brain-robot technology that translates the user's brain activity into motor commands to drive powered, assist-as-needed, upper-limb robotics for stroke rehabilitation. Feedback of performance will be provided to both the patient and the clinician, and stored for monitoring and diagnostics, through a user interface that also serves to provide engaging real-time feedback of task and associated completion performance. System validation will occur in a clinical setting and at home. The Intellectual Merits include addressing the challenges of fault-tolerant system integration, low-cost device prototyping, usability, shared-control, acquiring validation data, and accelerating the translation to the patient for a new class of biomedical devices. The deliverable is an accessible, safe and effective brain-controlled therapeutical robot system that is multi-functional with real-time self-monitoring, self-diagnostics and self-correcting capabilities, and that promotes neurorecovery of function.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.