Macromolecular Self-Assembly of Amyloid Fibrils

蛋白质的错误折叠是公共卫生中的一个关键问题。常见的疾病，如阿尔茨海默病，2型糖尿病和心脏病与蛋白质错误折叠有关，并对社会产生重大影响。蛋白质作为治疗药物的使用现在很常见（例如作为疫苗，用于免疫疾病），但它们可能因蛋白质错误折叠而变得无效或有害。通过这个项目，我们将加强对蛋白质在溶液中，固体表面和剪切下组装过程的基本理解。

The misfolding of proteins is a key issue in public health. Common diseases, such as Alzheimer's disease, type 2 diabetes, and heart disease are associated with protein misfolding, and have a major impact on society. The use of proteins as therapeutic drugs is now common ( e.g. as vaccines, for immune disorders) but they can be rendered ineffective or harmful by protein misfolding. Through this project, we will enhance the fundamental understanding of the processes of protein assembly in solution, at solid surfaces, and under shear.