RoL: FELS - Workshop on Multiscale Modeling in Biology

该项目支持将于2019年5月20日至22日在明尼苏达大学举行的“生物学多尺度建模”研讨会。从分子和细胞水平到组织和有机体水平，生物系统通常涉及跨越空间和时间尺度的复杂过程。多尺度数学模型的发展，能够解决在每个尺度现象之间的相互作用，有助于理解这些过程。会议的目的是促进研究人员之间的思想交流，在不同的生物应用中使用常见的多尺度建模框架。会议的重点将是跨越分子、细胞和组织尺度的数学模型，重点是涉及信号转导、形状变化、运动和生长的问题。各种生物应用领域将有代表，包括组织组织，发展和癌症。一个关键的主题将是力学和生物化学的相互作用，这是许多这些问题的核心。为此，18位已确认的演讲者将介绍新的多尺度技术的发展及其在反应动力学、信号网络、细胞运动、发育和肿瘤动力学方面的应用。此外，研讨会将汇集新一代的研究人员与已建立的专题专家，以培养新的合作和网络。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The project supports a workshop on 'Multiscale Modeling in Biology', to be held on May 20-22, 2019 at the University of Minnesota. Biological systems often involve complex processes that span spatial and temporal scales, ranging from the molecular and cell levels to the tissue and organism levels. The development of multiscale mathematical models, capable of resolving the interaction between phenomena at each scale, is instrumental in understanding these processes. The conference aims to foster an exchange of ideas between researchers working in diverse biological applications using common multiscale modeling frameworks.The focus of the conference will be on mathematical models spanning the molecular, cellular and tissue scales, with an emphasis on problems that involve signal transduction, shape changes, movement, and growth. A variety of biological application areas will be represented, including tissue organization, development, and cancer. A key theme will be the interplay of mechanics and biochemistry, which is central to many of these problems. To this end, 18 confirmed speakers will present work spanning the development of new multiscale techniques and their application in reaction dynamics, signaling networks, cell motility, development and tumor dynamics. In addition, the workshop will bring together a new generation of researchers with established topical experts to cultivate new collaborations and networks.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.