CAREER: Advancing Ion Concentration Polarization to Enrich New Classes of Analytes from Complex Media and to Interface with Analysis: Breaking the Glass Ceiling on Enrichment

爱荷华州立大学的robyn Anand教授得到了化学系化学测量和成像项目的支持，致力于开发分析技术，解决目前在从难以处理的流体中选择性分离和富集化合物方面的限制。新开发的技术在富集位点灵敏地检测分离的化合物。重点是目前无法进入的化合物类别，包括药物、食品添加剂以及存在于生物液体、食品和药物制剂中的临床相关靶点。该项目通过更准确的医疗诊断和保证高质量的食品和药品来改善公众健康，从而对社会产生积极影响。该项目支持开发一门研讨会式的大学课程，通过让学生参与讨论工作与生活的平衡、工作环境、创业精神和网络等主题，促进科学的多样性。此外，案例研究的发展，以提高学习成果的研究生水平的电化学教材。该项目解决了电动分离和富集领域的一个重大挑战。即，它适用于复杂介质中不带电的物种，以及分离平台与下游检测和定量方法的集成。长期目标是通过开发和标准化通用和可重复的化学过程，扩大基于离子浓度极化概念的电动聚焦的适用性。新的离子浓度极化策略，解决目前的限制进行了研究。这些策略利用客-主相互作用将电荷传递给中性物种；贫离子带在粘性流体中的起始、生长和稳定性的独特特性；三维流动电极结构提高了原位检测的灵敏度。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Professor Robbyn Anand of Iowa State University is supported by the Chemical Measurement and Imaging Program of the Division of Chemistry to develop analytical techniques that address current limitations to the selective separation and enrichment of chemical compounds from difficult to handle fluids. The newly developed technique sensitively detects the separated compounds at the site of enrichment. The focus is on currently inaccessible categories of compounds, including medications, food additives, and clinically-relevant targets present in biological fluids, food, and pharmaceutical formulations. The project positively impacts society by improving public health through more accurate medical diagnostics and the assurance of high quality food and medications. The project supports the development of a workshop-style college course to promote diversity in science by engaging students in discussions on topics such as work-life balance, workplace climate, entrepreneurship, and networking. In addition, case studies are developed to improve learning outcomes in graduate-level electrochemistry educational material. The project tackles a major challenge in the field of electrokinetic separations and enrichment. Namely, its applicability to uncharged species in complex media and the integration of the separation platform with downstream detection and quantification methodologies. The long-term objective is to broaden the applicability of electrokinetic focusing that is based on the concept of ion concentration polarization through the development and standardization of versatile and reproducible chemical processes. New ion concentration polarization strategies that address current limitations are investigated. These strategies take advantage of guest-host interactions that impart charge to neutral species; unique features of ion depleted zone initiation, growth, and stability in viscous fluids; and the enhanced sensitivity of in situ detection with three-dimensional flow-through electrode architectures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.