Enantioselective Catalysis Enabled by Imidazole-Based Biaryl Ligands

有了这个奖项，化学系的化学合成计划正在支持佛罗里达大学化学系的Aaron Aponick教授的研究。 该项目的重点是设计新型含金属配合物，用于合成农业，清洁能源技术和制药中使用的有机化合物。化学工业依赖于这些反应作为比经典反应化学更容易生产新化合物和材料的手段（具有更少的能量、时间或所需的分离）。 由Aponick教授领导的团队正在开发催化剂，这些催化剂有望在先进制造业中应用。该项目还为学生提供实践培训。 公共宣传是通过在佛罗里达大学的公开讲座来实现的。公众宣传还包括化学日在商场，分子躁狂症。这项活动深受儿童欢迎，并促进与公众的互动。化学系的化学合成项目支持佛罗里达大学化学系的Aaron Aponick教授的研究，他正在开发一类新的均相催化配体。His“P-N”配体在阻转异构手性联芳基骨架中引入咪唑取代基。 许多P，N-配体是已知的，但Aponick教授的咪唑基系统表现出独特的，往往是上级催化行为。 该研究的一个主要目的是阐明这种模块化配体平台赋予的反应性和选择性的基本原理。 机理研究正在被用来提供对有机金属化学的基本理解。 Aponick小组正在利用动力学和晶体学研究来询问这些所谓的Stack配体的配位化学如何影响催化活性。 进一步的研究利用更基本的和几何约束的咪唑部分，使新的反应，依赖于什么似乎是一个双功能和半不稳定的配位基序。 利用这种策略，正在开发新的对映选择性铜和钯催化反应。这项研究计划为学生提供实践培训。 该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With this award, the Chemical Synthesis Program of the Division of Chemistry is supporting the research of Professor Aaron Aponick of the Department of Chemistry at the University of Florida. The project focuses on the design of new kinds metal-containing complexes used in the synthesis of organic compounds used in agriculture, clean energy technologies and pharmaceuticals. The chemical industry relies on such reactions as means of producing new compounds and materials more easily than classical reaction chemistry (with less energy, time or required separations). The team led by Professor Aponick is developing catalysts that show promise for the applications in advanced manufacturing. This project also provides hands-on training for students. Public outreach is achieved by public lectures at the University of Florida. Public outreach also includes Chemistry Day at the Mall, Molecular Mania. This event is popular with children and fosters interactions with the public in general. Many visitors with diverse socioeconomic backgroundsparticipate.The Chemical Synthesis Program of the Division of Chemistry is supporting the research of Professor Aaron Aponick of the Department of Chemistry at the University of Florida who is developing a new class of ligands for homogeneous catalysis. His "P-N" ligands incorporates imidazole substituents in an atropisomeric chiral biaryl backbone. Many P,N-ligands are known, but Professor Aponick's imidazole-based systems exhibit distinctive and often superior catalytic behavior. A major aim of the research is to elucidate the principles underpinning the reactivity and selectivity imparted by this modular ligand platform. Mechanistic studies are being employed to provide a fundamental understanding of the organometallic chemistry. The Aponick group is utilizing kinetic and crystallographic studies to interrogate how the coordination chemistry of these so-called Stack-ligands influences the catalytic activity. Further studies utilize the more basic and geometrically constrained imidazole moiety to enable new reactions that rely on what appears to be a bifunctional and hemilabile coordination motif. With this strategy, new enantioselective copper- and palladium-catalyzed reactions are being developed. This research program is providing hands-on training for students. Their professional development is emphasized in all aspects of the work.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.