Metrology for biomedical applications of magnetic hybrid materials

该项目的目的是开发和应用基于磁弛豫测量（MRX）和磁粒子光谱（MPS）以及磁粒子成像（MPI）的磁测量程序，这将能够定量描述粒子基质相互作用，特别是在存在额外磁场和流动介质的情况下。我们将主要集中在物理上定义良好的磁性混合材料，以便将测量的磁性参数与相关的相互作用参数相关联。这些混合材料将作为模型来描述更复杂的生物医学应用环境中的颗粒基质相互作用，例如热疗、磁性热消融、成像中的造影剂（MRI、MPI）、磁性药物靶向或使用磁性纳米颗粒的磁转染。在最后阶段，开发的磁性测量程序应能够评估磁性纳米颗粒与其生物基质在上述体内应用中的相互作用。

The aim of the project is the development and application of magnetic measurement procedures based on magnetorelaxometry (MRX) and magnetic particle spectroscopy (MPS), and magnetic particle imaging (MPI), that will enable to describe quantitatively the particle matrix interaction, in particular in the presence of additional magnetic fields and in flowing media. We will focus primarily on physically well-defined magnetic hybrid materials in order to relate the measured magnetic parameters to the relevant interaction parameters. These hybrid materials shall serve as models to describe the particle Matrix interaction in the far more complex biomedical application settings such as hyperthermia, magnetic thermoablation, contrast agent in imaging (MRI, MPI), magnetic drug targeting or magnetofection using magnetic nanoparticles. In the final stage, the developed magnetic measurement procedures shall enable the assessment of the interaction of magnetic nanoparticles with their biological matrix in the above mentionedin-vivo applications.