Bilateral decision networks for eye and arm movements

Igor Kagan和Melanie Wilke将研究顶叶区LIP和PRR在与眼睛和手臂运动相关的决策中的作用。通过对这些区域进行双半球同步记录，结合单侧可逆失活，该小组将研究双侧神经元网络如何处理视觉信息，以达成与跳眼和手臂到达运动计划相关的决策，以及受损半球的神经元扰动如何影响完整半球的活动。然后将这些实验的峰值和局部场电位（LFP）活动与同时进行的灵长类动物功能磁共振成像实验进行比较，这些实验将采用类似的设计。这些实验将揭示来自两个半球的特定神经元基质如何竞争和合作以达成行动决策，以及半球间平衡受损如何导致失活诱导的缺陷。

Igor Kagan and Melanie Wilke will investigate the role of intra- and inter-hemispheric interactions in the parietal areas LIP and PRR for decision-making related to eye and arm movements. By performing bi-hemispheric simultaneous recordings from these areas, in combination with unilateral reversible inactivation, this group will investigate how this bilateral neuronal network processes visual information to arrive at decisions related to the planning of saccadic eye and arm reaching movements, and how neuronal perturbations in the lesioned hemisphere affect the activity in the intact hemisphere. Spiking and local field potential (LFP) activity from these experiments will then be compared to concurrent primate fMRI experiments that will employ a similar design. These experiments will shed new light on how specific neuronal substrates from both hemispheres compete and collaborate for arriving at decisions for actions, and how the impaired inter-hemispheric balance causes inactivation-induced deficits.