Combinatorial search for novel transformations catalyzed by transition metal complexes carrying fluoroalkylphosphines as ligands

3D筛选模式是对Robbins和Hartwig为发现新的催化过程而开发的高通量筛选方法的一种改进，应加以详细阐述，然后应用于寻找含氟烷基取代膦的过渡金属络合物催化的新反应。这类配体结合了强大的pi受体性质和可变的空间体积，因此，可能能够催化具有立体控制潜力的不寻常的过程。由于氟烷基膦的应用很少，而且大多局限于对已知过程的改进，因此使用高通量方法来识别氟烷基膦络合物催化的新转化特别有价值。

3D screening mode - a modification of the high throughput screening method developed by Robbins and Hartwig for discovery of new catalytic processes - shall be elaborated and then applied to the search for new reactions catalyzed by transition metal complexes containing fluoroalkyl-substituted phosphines. This class of ligands combines strong pi-acceptor properties with variable steric bulk, and, therefore, might be able to catalyze unusual processes with the potential for stereocontrol. Because only few applications of fluoroalkyl phosphines are known and these are mostly restricted to the modifications of well-known processes, use of the high throughput methods should be especially valuable to identify new transformations catalyzed by complexes of fluoroalkylphosphines.