STAT6-regulated B cell responses in type 2 immunity (20)

已知转录因子STAT 6是免疫球蛋白类别转换为IgE所需的。此外，项目20发现了STAT 6在B细胞中对于2型免疫中的生发中心（GC）反应的调节的关键作用，并通过组合的蛋白质组/转录组进一步鉴定了B细胞中的许多STAT 6调节的基因。此外，该项目可以表明IgE-BCR的免疫酪氨酸尾基序是IgE+浆细胞（PC）扩增所需的。在下一个资助期内，该项目将确定不同的STAT 6调控基因对GC形成的作用，表征蠕虫衍生的B细胞抗原，并通过GC衍生细胞的命运图谱监测记忆B细胞和长寿PC的发育。

The transcription factor STAT6 is known to be required for immunoglobulin class switching to IgE. In addition, project 20 found a critical role of STAT6 in B cells for regulation of the germinal center (GC) reaction in type 2 immunity and further identified numerous STAT6-regulated genes in B cells by a combined proteome/transcriptome. In addition, this project could show that the immunotyrosine tail motif of the IgE-BCR was required for expansion of IgE+ plasma cells (PCs). In the next funding period this project will determine the role of distinct STAT6-regulated genes for GC formation, characterize helminth-derived B cell antigens and monitor the development of memory B cells and long-lived PCs by fate mapping of GC-derived cells.