Build and Broaden: Growing Capacity in Southeast Alaska Indigenous Genomic Research Partnerships

该项目将支持在阿拉斯加东南部的Tlingit，Haida和Tsimshian社区内建立基因组研究伙伴关系的区域方法。一系列研讨会将通过动手实验室练习向阿拉斯加东南部土著社区代表的工作组介绍基本的基因组研究方法。该工作组将制定文化响应的基因组研究政策建议和资源，作为其他土著社区，机构及其合作者的潜在模式。与Sealaska Heritage Institute的STEAM计划合作，工作组的见解也将应用于为阿拉斯加土著中学生开发基于地方的，文化响应的基因组实验室教学模块。这种教学模式将是感兴趣的其他STEM教育工作者服务土著学生群体。研讨会的活动将加强现有的基因组研究之间的合作伙伴关系的调查，并进一步支持阿拉斯加原住民博士后研究员（PI贝德）的培训和专业化。拟议的系列研讨会将建立在阿拉斯加州东南部的原住民社区和阿拉斯加遗产研究所的能力，从事公平的基因组研究伙伴关系，特别是与非土著合作者。讲习班活动将为土著社区及其合作者制作一个基因组研究资源工具包。该工具包将包括基因组研究政策建议，该建议将使基因组研究人员对社区核心文化价值观负责，为希望与阿拉斯加东南部土著社区进行基因组研究的研究人员提供文化能力培训模块，以及MOU/MOA和知情同意等文件的示例，这些文件将突出社区及其研究伙伴之间讨论的关键点。联盟出版物将推荐基因组研究关键要素的方法（例如，样本管理和数据共享），这些方法由阿拉斯加州东南部土著社区的核心价值观提供信息。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This project will support a regional approach to building capacity for genomic research partnerships within the Tlingit, Haida, and Tsimshian communities of southeast Alaska. A workshop series will introduce a working group of southeast Alaska Indigenous community representatives to basic genomic research methods through hands-on laboratory exercises. The working group will develop culturally-responsive genomic research policy recommendations and resources that will serve as a potential model for other Indigenous communities, institutions, and their collaborators. In collaboration with Sealaska Heritage Institute’s STEAM program, insight from the working-group will also be applied to developing a place-based, culturally-responsive genomic laboratory teaching module for Alaska Native middle school students. This pedagogical model will be of interest to other STEM educators serving Indigenous student populations. The workshop activities will strengthen the existing genomic research partnerships between the investigators and further support the training and professionalization of an Alaska Native postdoctoral fellow (PI Bader).The proposed workshop series will build capacity in southeast Alaska Native communities and the Sealaska Heritage Institute to engage in equitable genomic research partnerships, especially with non-Indigenous collaborators. Workshop activities will produce a genomic research toolkit of resources for Indigenous communities and their collaborators. This toolkit will include a genomic research policy recommendation that will hold genomic researchers accountable to community core cultural values, a cultural competency training module for researchers who wish to engage in genomic research with Indigenous communities in southeast Alaska, and examples of documents like MOU/MOA and informed consent which will highlight key points to be discussed between communities and their research partners. Consortium publications will recommend approaches to critical elements of genomic research (for example, sample management and data sharing) informed by the core values of southeast Alaska Native communities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.