MRI: Acquisition of a High Resolution Mass Spectrometer for Education and Research

该奖项由主要研究仪器和化学研究仪器计划支持。坦帕大学正在购买一台高分辨率质谱仪，该质谱仪配备了轨道阱分析仪、真实的实时直接分析（DART）接口和超高压液相色谱（UPLC）装置，以支持Kenyon Evans-Nguyen及其同事Kelly Deister、Michelle克罗斯比和克莉丝汀西奥多。一般来说，质谱（MS）是用于识别和表征复杂样品中少量化学物质的关键分析方法之一。 具有高分辨率液相色谱部分的仪器通过在化合物到达质谱仪之前分离化合物的混合物来提供额外的结构鉴定能力。真实的直接分析是产生电子或振动激发态物质（例如氦、氩或氮）的离子源，所述离子源激发大气分子，所述大气分子然后与待分析的样品分子进行离子-分子反应。该仪器通过让不同的学生参与这种现代分析技术来扩大参与。UPLC-MS/MS系统被广泛用于培养本科生和高中生，并被邻近机构的合作者所使用。UPLC-MS/MS系统的授予旨在加强各级的研究和教育。它特别适用于定量，表征化合物，以开发先进的数据集，以帮助天然产物的研究。该仪器还用于表征污染物在坦帕湾的空间和时间分布。 该仪器还为研究人员提供了表征和分析生物标本中新精神活性物质（也称为滥用物质）的服务。一个重要的用途是开发和建设的环境电离源能够结合分子，有机和元素分析的应用在forensic science.This奖项反映了NSF的法定使命，并已被认为是值得的支持，通过评估使用基金会的知识价值和更广泛的影响审查标准。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of Tampa is acquiring a high resolution mass spectrometer equipped with an orbitrap analyzer, a direct analysis in real time (DART) interface and an ultrahigh pressure liquid chromatography (UPLC) unit to support Kenyon Evans-Nguyen and colleagues Kelly Deister, Michelle Crosby and Christine Theodore. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. An instrument with a high resolution liquid chromatography sector provides additional structural identification power by separating mixtures of compounds before they reach the mass spectrometer. The direct analysis in real time is an ion source that produces electronically or vibronically excited-state species such as helium, argon or nitrogen that ionize atmospheric molecules which then undergo ion-molecule reactions with the sample molecules to be analyzed. The instrument broadens participation by involving diverse students with this modern analytical technique. It is extensively used to train undergraduate and high school students and by collaborators at neighboring institutions.The award of the UPLC-MS/MS system is aimed at enhancing research and education at all levels. It is especially useful for quantifying, characterizing compounds to develop advanced data sets to aid natural products research. The instrumentation is also used for characterizing the spatial and temporal distributions of contaminants in Tampa Bay. The instrument also serves researchers characterizing and analyzing new psychoactive substances (NPS), also known as substances of abuse, in biological specimens. An important use is for the development and construction of ambient ionization sources capable of combined molecular, organic, and elemental analysis for applications in forensic science.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.