Planning for National Ultrahigh Field Nuclear Magnetic Resonance (NMR) Network

在生物基础设施部和材料研究部的支持下，特拉华大学获得了设计和开发超高场（UHF）核磁共振（NMR）光谱仪设施国家网络的计划。该项目的总体目标是建立世界上最强大的核磁共振网络，拥有全面的资源和专业知识，跨越NSF感兴趣的关键领域，这将对美国境内的整个科学界开放。灵敏度、分辨率和信息内容的增益与磁场强度高度非线性，超高磁场与最先进的核磁共振探针和脉冲序列相结合，将使当前技术无法实现的紧急现象的原子分辨率的基础研究成为可能。最先进的超高频核磁共振仪器将被安置在地理上分布在美国各地的战略性公共机构。核磁共振网络将提供给跨多个学科的研究人员，以推进体内、体外、原位、溶液和固态核磁共振光谱的开发和使用，以解决具有高度基础和技术重要性的各种问题。仪器将通过中央网络基础设施枢纽连接，并与其他高场和超高频核磁共振仪器集成。拟议的全国超高频核磁共振网络将使专家和非专家能够访问超高频核磁共振仪器和各种核磁共振专业知识。通过提议的网络建立的知识框架将为学生提供最先进的核磁共振方法和应用的独特培训。外展计划包括核磁共振仪器和核磁共振方法的应用培训，对下一代科学家的发展将是无价的。规划超高频核磁共振网络将为解决全国对超高场核磁共振基础设施的迫切需求奠定基础。该合同支持的规划活动将确定UHF核磁共振网络的主要科学、技术和系统性能要求以及相关设计和规范。通过这些活动，研究人员将制定执行和管理UHF核磁共振网络的计划，包括确定风险的项目时间表和减轻风险的计划，用于跟踪进度、成本和性能的治理计划和有效的项目管理方法。这项工作的结果将包括对实施和预期的操作和维护成本进行合理的基线成本估算。研究人员还将制定有效的学生培训计划，并在仪器、设备开发和数据分析方面参与多样化的劳动力。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With support from both the Division of Biological Infrastructure and the Division of Materials Research, an award is made to the University of Delaware to design and develop plans for a national network of ultrahigh field (UHF) nuclear magnetic resonance (NMR) spectrometer facilities. The overall goal of the project will be to create the most powerful NMR network in the world with comprehensive resources and expertise, spanning key areas of NSF interest, that will be accessible to the entire scientific community within the United States. Gains in sensitivity, resolution, and information content are highly nonlinear with magnetic field strength, and ultrahigh fields combined with state-of-the-art NMR probes and pulse sequences will enable fundamental investigations, with atomic resolution, of emergent phenomena not accessible with the current technologies. State-of-the-art UHF NMR instruments will be sited at strategically located public institutions geographically distributed across the US. The NMR network will be made available to researchers across multiple disciplines for advancing the development and use of in vivo, in vitro, in situ, solution, and solid-state NMR spectroscopy to address diverse problems of high fundamental and technological importance. Instruments will be connected through a central cyberinfrastructure hub and integrated with other high-field and UHF NMR instrumentation. The proposed nationwide UHF NMR network will enable experts and non-experts to access both UHF NMR instruments and a diversity of NMR expertise. The intellectual framework established through the proposed network will provide unique training for students in state- of-the-art NMR methods and applications. The outreach program encompassing training in NMR instrumentation and application of NMR methods will be invaluable for the development of the next generation of scientists.Planning the UHF NMR network will set the stage to address the urgent nationwide need for ultrahigh field NMR infrastructure. The planning activities supported by this award will identify the primary scientific, technical and system performance requirements and associated designs and specifications for the UHF NMR network. Through these activities, the researchers will formulate a plan to execute and manage the UHF NMR network, including a project schedule with identified risks and plans to mitigate them, a governance plan and effective project management methods for tracking progress, costs and performance. Outcomes from this effort will include sound baseline cost estimates for implementation and anticipated operations and maintenance costs. The researchers will also develop plans for effective student training and the involvement of a diverse workforce in instrumentation, facility development, and data analysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.