Mid-scale RI-1 (M1:IP): 1.2 GHz NMR Spectrometer for National Gateway Ultrahigh Field NMR Center

俄亥俄州立大学被授予在National Gateway超高场核磁共振中心购买、安装和操作最先进的超高场1.2 GHz核磁共振(核磁共振)光谱仪的奖项。这一新一代核磁共振仪器将提供美国目前缺乏的关键研究基础设施，提高我们的经济竞争力，并对能源转换和存储、新材料、分子建模、合成生物学、诊断方法、药物设计和个性化医学等多个领域产生重大影响。该中心将提供独特的机会来吸引和培训本科生、研究生和博士后级别的年轻STEM科学家，包括那些来自代表性不足的群体的科学家，他们在核磁共振研究人员中所占的比例迅速增长。将通过地方讲习班、地区性Gateway核磁共振会议、高中日、行业日以及国家讲习班和会议来促进对核磁共振概念和应用的积极学习。这些活动将增加国家和地区核磁共振社区内的学术和行业伙伴关系，以实现1.2 GHz核磁共振的许多科学承诺。在过去的几年里，俄亥俄州立大学已经建立了全国最大和最先进的共享核磁共振设施之一，作为校园化学仪器中心(CCIC)的一部分。核磁共振的非侵入性、非破坏性、定量和高度重复性使其成为最通用的物理技术之一，提供了对无数分子系统和材料的内部工作原理的原子细节洞察，其中许多具有巨大的复杂性和非凡的性质。高温超导(HTS)线材技术的最新发展使下一代超高场核磁共振磁体的建造成为可能，最高可达1.2 GHz。俄亥俄州立大学购买1.2 GHz核磁共振仪器将满足国家和地区对这种仪器的迫切需求，使从根本上解决新的科学问题的变革性研究能够在大量化学和生化系统中进行。这些研究包括纳米和非晶态材料的微观性质，大的和/或弱的蛋白质和RNA复合体的生物分子结构、动力学和功能，本质上无序的蛋白质及其与纳米材料的相互作用，以及代谢组学。这项研究将使人们能够在分子水平上更深入地了解生物的相互作用、交流和功能，并为设计具有新性能的材料提供支持。1.2 GHz核磁共振波谱仪将作为一个国家中心运营，既有地区用户，也有来自美国各地的用户，包括来自学术界、国家实验室和工业界的用户。该项目得到了基金会范围的中型研究基础设施计划的支持。该项目将由生物科学局内的生物基础设施司管理。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to the Ohio State University to acquire, install, and operate a state-of-the-art ultrahigh field 1.2 GHz nuclear magnetic resonance (NMR) spectrometer at the National Gateway Ultrahigh Field NMR Center. This next generation NMR instrument will provide critical research infrastructure that is currently lacking in the US, increasing our economic competitiveness with substantial impact on diverse areas, such as energy conversion and storage, new materials, molecular modeling, synthetic biology, diagnostic approaches, drug design, and personalized medicine. The Center will provide unique opportunities to attract and train young STEM scientists at the undergraduate, graduate and postdoctoral levels, including those from underrepresented groups, who constitute a rapidly growing fraction of NMR researchers. Active learning of NMR concepts and applications will be promoted through local workshops, the regional Gateway NMR conference, a high school day, an industry day, and national workshops and conferences. These activities will increase academic and industry partnerships within the national and regional NMR communities to carry the many scientific promises of NMR at 1.2 GHz to fruition. Over the past several years, OSU has built one of the largest and most advanced shared NMR facilities in the nation as part of the Campus Chemical Instrument Center (CCIC). NMR's non-invasive, non-destructive, quantitative, and highly reproducible nature has turned it into one of the most versatile physical techniques providing atomic detail insights into the inner workings of a myriad of molecular systems and materials, many of which have enormous complexity and extraordinary properties. Recent developments in high-temperature superconducting (HTS) wire technology have allowed the construction of next generation ultrahigh field NMR magnets up to 1.2 GHz. The acquisition of a 1.2 GHz NMR instrument at OSU will fulfill an urgent national and regional need for such instrumentation, enabling transformative research that addresses fundamentally new scientific questions to be carried out for a large number of chemical and biochemical systems. These include microscopic properties of nano- and non-crystalline materials, biomolecular structure, dynamics, and function of large and/or weak protein and RNA complexes, intrinsically disordered proteins and their interactions with nanomaterials, and metabolomics. This research will enable a deeper understanding of biological interactions, communication, and function at the molecular level and support the design of materials with novel properties. The 1.2 GHz NMR spectrometer will be operated as a national center with both regional users and those from across the US, including users from academia, national labs, and industry. This project is supported by the Foundation-wide Mid-scale Research Infrastructure program. The project will be managed by the Division for Biological Infrastructure within the Directorate for Biological Sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.