Mid-scale RI-1 (M1:IP): 1.2 GHz NMR Spectrometer for National Gateway Ultrahigh Field NMR Center

中型 RI-1 (M1:IP)：用于 National Gateway 超高场 NMR 中心的 1.2 GHz NMR 波谱仪

• 批准号: 1935913
• 负责人: Rafael Bruschweiler
• 金额: $ 1757.72万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1935913&HistoricalAwards=false
• 关键词: Mid; scale; RI; M1; IP

An award is made to the Ohio State University to acquire, install, and operate a state-of-the-art ultrahigh field 1.2 GHz nuclear magnetic resonance (NMR) spectrometer at the National Gateway Ultrahigh Field NMR Center. This next generation NMR instrument will provide critical research infrastructure that is currently lacking in the US, increasing our economic competitiveness with substantial impact on diverse areas, such as energy conversion and storage, new materials, molecular modeling, synthetic biology, diagnostic approaches, drug design, and personalized medicine. The Center will provide unique opportunities to attract and train young STEM scientists at the undergraduate, graduate and postdoctoral levels, including those from underrepresented groups, who constitute a rapidly growing fraction of NMR researchers. Active learning of NMR concepts and applications will be promoted through local workshops, the regional Gateway NMR conference, a high school day, an industry day, and national workshops and conferences. These activities will increase academic and industry partnerships within the national and regional NMR communities to carry the many scientific promises of NMR at 1.2 GHz to fruition. Over the past several years, OSU has built one of the largest and most advanced shared NMR facilities in the nation as part of the Campus Chemical Instrument Center (CCIC). NMR's non-invasive, non-destructive, quantitative, and highly reproducible nature has turned it into one of the most versatile physical techniques providing atomic detail insights into the inner workings of a myriad of molecular systems and materials, many of which have enormous complexity and extraordinary properties. Recent developments in high-temperature superconducting (HTS) wire technology have allowed the construction of next generation ultrahigh field NMR magnets up to 1.2 GHz. The acquisition of a 1.2 GHz NMR instrument at OSU will fulfill an urgent national and regional need for such instrumentation, enabling transformative research that addresses fundamentally new scientific questions to be carried out for a large number of chemical and biochemical systems. These include microscopic properties of nano- and non-crystalline materials, biomolecular structure, dynamics, and function of large and/or weak protein and RNA complexes, intrinsically disordered proteins and their interactions with nanomaterials, and metabolomics. This research will enable a deeper understanding of biological interactions, communication, and function at the molecular level and support the design of materials with novel properties. The 1.2 GHz NMR spectrometer will be operated as a national center with both regional users and those from across the US, including users from academia, national labs, and industry. This project is supported by the Foundation-wide Mid-scale Research Infrastructure program. The project will be managed by the Division for Biological Infrastructure within the Directorate for Biological Sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

授予俄亥俄州州立大学在国家网关超高场核磁共振中心获得、安装和操作最先进的1.2 GHz核磁共振（NMR）光谱仪的奖项。 这种下一代核磁共振仪器将提供美国目前缺乏的关键研究基础设施，提高我们的经济竞争力，对能源转换和储存、新材料、分子建模、合成生物学、诊断方法、药物设计和个性化医疗等各个领域产生重大影响。该中心将提供独特的机会，吸引和培养本科生，研究生和博士后水平的年轻STEM科学家，包括那些来自代表性不足的群体，他们构成了NMR研究人员的快速增长部分。将通过地方讲习班、区域网关NMR会议、高中日、工业日以及国家讲习班和会议促进积极学习NMR概念和应用。这些活动将增加国家和地区NMR社区内的学术和工业伙伴关系，以实现1.2 GHz NMR的许多科学承诺。在过去的几年里，OSU已经建立了全国最大，最先进的共享NMR设施之一，作为校园化学仪器中心（CCIC）的一部分。 NMR的非侵入性，非破坏性，定量和高度可重复性的性质使其成为最通用的物理技术之一，为无数分子系统和材料的内部工作提供原子细节见解，其中许多具有巨大的复杂性和非凡的特性。 高温超导（HTS）导线技术的最新发展允许建造下一代高达1.2 GHz的磁场NMR磁体。 在俄勒冈州立大学购买1.2 GHz NMR仪器将满足国家和地区对此类仪器的迫切需求，从而能够为大量化学和生物化学系统进行变革性研究，解决根本性的新科学问题。这些包括纳米和非晶体材料的微观特性，生物分子结构，动力学，以及大和/或弱蛋白质和RNA复合物的功能，本质上无序的蛋白质及其与纳米材料的相互作用，以及代谢组学。这项研究将使人们能够更深入地了解分子水平上的生物相互作用、通信和功能，并支持设计具有新特性的材料。1.2 GHz NMR光谱仪将作为一个国家中心运行，区域用户和来自美国各地的用户，包括来自学术界、国家实验室和工业界的用户。 该项目由基金会范围内的中型研究基础设施计划支持。 该项目将由生物科学理事会生物基础设施处管理。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。