The Endoplasmic Reticulum (ER) Conference: Structure, Function and Disease

该奖项将支持FASEB关于内质网（ER）的结构，功能和与疾病的关系的会议，将于2023年6月11日至15日在佛罗里达州墨尔本的墨尔本海滨皇冠假日酒店举行。这将聚集在一起讨论我们对ER的生物学和功能的各个方面的理解，ER是围绕细胞核的复杂结构，它调节细胞中蛋白质和脂肪的形成和破坏。 讲座将介绍的主题，如蛋白质如何形成和修改，以在细胞内外发挥作用，脂肪水平如何在细胞中调节，以及ER如何感知和响应压力，以维持其基本功能。 除了正式的会谈，参与将通过两个扩展海报会议促进研究人员之间的互动。 NSF的支持将用于支付旅行和注册费用，为与会者的子女提供托儿支持，并允许参与者在其职业生涯的早期阶段参加，特别是在该领域代表性不足的群体的成员。内质网是所有真核细胞内存在的一种重要的，可以说是最复杂的细胞器。 ER功能是蛋白质和脂质合成和周转的核心，ER含有强大的应激反应途径，用于增强ER功能，以响应潜在的毒性条件或发育线索。 会议将汇集经验丰富的研究人员与学生和早期职业科学家在正式会谈和讨论会，鼓励非正式讨论和最新研究成果的合成，折叠和蛋白质，脂质动力学和储存，ER结构重塑和ER-细胞器通信营业额的分享，和展开的蛋白质反应。该领域的最新进展，包括新的技术能力，将得到强调。该奖项由生物科学理事会分子和细胞生物科学部的细胞动力学和功能组资助。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award will support a FASEB Meeting on the structure, function, and relationship to disease of the endoplasmic reticulum (ER), to be held June 11-15, 2023 at the Crowne Plaza Melbourne-Oceanfront Hotel in Melbourne, FL. Meeting attendees will include graduate students and postdoctoral fellows, as well as senior researchers, that will gather to discuss our understanding of all aspects of the biology and function of the ER, the complex structure that surrounds the cell nucleus and which regulates the formation and destruction of proteins and fats in cells. Talks will be presented on topics such as how proteins are formed and modified to function within and outside of cells, how fat levels are regulated in the cell, and how the ER senses and responds to stress to maintain its essential functions. In addition to formal talks, engagement will be facilitated by two extended poster sessions to stimulate interactions between researchers. NSF support will be used to defray travel and registration costs, to provide childcare support for children of attendees, and to allow attendance of participants during early stages of their careers, especially members of groups underrepresented in this field.The endoplasmic reticulum is an essential, and arguably the most complex, organelle present within all eukaryotic cells. ER function is central to the synthesis and turnover of both proteins and lipids, and the ER contains robust stress response pathways that serve to augment ER function in response to potentially toxic conditions or developmental cues. The meeting will bring together seasoned investigators with students and early-career scientists in both formal talks and discussion sessions to encourage informal discussion and the sharing of the latest research results on the synthesis, folding, and turnover of proteins, lipid dynamics and storage, ER structural remodeling and ER-organellar communication, and the unfolded protein response. Recent advances in the field, including new technological capabilities, will be highlighted. This award is funded by the Cellular Dynamics and Function Cluster of the Division of Molecular and Cellular Biosciences in the Directorate for Biological Sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.