I-Corps: Portable airbrush-based device to treat hemorrhage and promote accelerated healing of traumatic wounds

这个I-Corps项目的更广泛的影响/商业潜力是开发一种便携式技术，旨在阻止严重出血并提供长期全面的伤口护理。 在美国，30%到40%的平民死于创伤是由于出血，这是战场上死亡的主要原因。 目前，用于解决出血的技术都没有被批准长期使用。 拟议的技术旨在密封和愈合创伤性伤口，而无需缝合，并可用于治疗枪击受害者和其他创伤性伤口。 此外，它可以由前线的非专家或平民急救人员操作，并可以提供全面的长期伤口护理。这一点在枪支暴力上升、急诊室不堪重负的大流行病情况下以及世界偏远地区获得医疗服务的机会有限的情况下尤为重要。此外，拟议的技术可用于治疗烧伤或褥疮中遇到的大面积表面，该技术也可用于治疗受伤的动物。I-Corps项目的基础是开发一种治疗出血和促进创伤伤口加速愈合的医疗器械。 这项技术使用一个由便携式二氧化碳气瓶提供动力的喷枪来推动丙酮中的聚合物溶液，其中悬浮着纳米姜黄、抗菌剂和止痛剂。溶剂在半空中蒸发，直接将生物活性和生物可吸收的纳米复合材料存款在伤口区域上，以当场止血，提供加速的伤口愈合和长期的伤口护理。 此外，该装置避免了第一反应者接触患者血液的可能性。已经用小鼠模型评价了该技术的止血和加速伤口愈合特性。 此外，该解决方案完全由FDA批准用于人类长期使用的成分组成，这可能代表了全面伤口护理的一个进步。 该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is the development of a portable technology designed to arrest severe bleeding and provide long-term comprehensive wound care. In the United States, thirty to forty percent of civilian deaths by trauma are the result of hemorrhage and it is the main cause of death on the battlefield. Currently, none of the technologies used to address hemorrhage are approved for long-term use. The proposed technology is designed to seal and heal traumatic wounds without the need for stitches, and may be used to treat gunshot victims and other traumatic wounds at the point of occurrence. In addition, it may be operated by a non-specialist on the war front or by civilian first responders, and may provide comprehensive long-term wound care. This is particularly important with the rise in gun violence, in pandemic-like situations where emergency rooms are overwhelmed, and in remote regions of the world where access to medical care is limited. In addition, the proposed technology may be used to treat large surface areas encountered in burns or bedsores, and the technology also may be developed to treat wounded animals.This I-Corps project is based on the development of a medical device to treat hemorrhage and promote accelerated healing of traumatic wounds. The proposed technology uses an airbrush powered by a portable CO2 cylinder to propel a polymer solution in acetone with suspended nano-turmeric, an anti-microbial agent, and an analgesic. The solvent evaporates midair to directly deposit a bioactive and bioresorbable nanocomposite on the wound area to arrest hemorrhage on the spot, provide accelerated wound healing, and long-term wound care. In addition, the device avoids the potential exposure of first responders to patient blood. The bleed arrest and accelerated wound healing properties of the technology have been evaluated with mouse models. Further, the solution is exclusively composed of ingredients that are FDA approved for long-term use in humans, which may represent a step forward in comprehensive wound care. The proposed device may arrest hemorrhage, prevent infection, promote accelerated wound healing, and help save lives globally.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.