NHC-stabilized nickel complexes in the C-F- und C-H-bond activation of polyfluorinated aromatics

该项目旨在为镍介导的氟有机化合物的操作开发化学计量和催化方案。在这个项目中，系统地研究了用一个或两个NHC(NHC=N-杂环卡宾)配体稳定的镍配合物在含氟芳烃的C-F-和C-H键活化反应中的应用，这些转化涉及的反应机理，与部分氟化底物和具有杂原子取代的氟化底物反应的键活化步骤的选择性，以及这些络合物在催化反应中的应用。该研究项目的一个长期目标是开发化学和区域选择性反应，用于将多氟构建块转移到有机分子，以及开发多氟芳烃的选择性官能化反应。

The project aims at the development of stoichiometric and catalytic protocols for nickel-mediated manipulations of fluoroorganic compounds. Within this project nickel complexes, which are stabilized with one or two NHC (NHC = N-Heterocyclic Carbene) ligands will be systematically investigated with respect to an application of these complexes in C-F- and C-H bond activation reactions of fluoroaromatics, the reaction mechanisms involved in these transformations, the selectivity of the bond activation step for the reaction with partially fluorinated substrates and fluorinated substrates with hetero atom substituents, as well as application of these complexes in catalytic reactions. A long term goal of the research project lies in the development of chemo- and regioselective reactions for the transfer of polyfluorinated building blocks to organic molecules and in the development of selective functionalization reactions of polyfluorinated arenes.