Decarboxylative Arylations in Natural Product Synthesis and Transfer Hydrofunctionalizations Using Cyclohexadienes

在第二个项目期，在第一个资助期开发的钯催化脱羧基-伽马-芳基化和其他方法将用于合成各种芳基四氢木脂素。与天然产物合成一起，项目的一部分致力于方法开发。沿着这些思路，计划将功能化的环己二烯衍生物用作钯和镍催化的烯烃转移氢功能化反应的试剂。除了环己二烯衍生物外，还将合成N-磺化二氢吡啶作为过渡金属催化的烯烃官能化转移氢化试剂。金属和配体的性质应该允许控制区域化学以及这种转化的立体选择性。此外，同样的芳香族试剂也将应用于自由基型转移氢功能化反应。

In the second project period, the Pd-catalyzed decarboxylative gamma-arylation and other methods developed during the first funding period will be applied to the synthesis of various aryltetralinlignanes. Along with natural product synthesis, one part of project is devoted to methods development. Along those lines, it is planned to use functionalized cyclohexadiene derivatives as reagents in Pd- and Ni-catalyzed alkene transfer hydrofunctionalizations. Besides cyclohexadiene derivatives, N-sulfonylated dihydropyridines will be prepared and studied as transfer hydrofunctionalization reagents in transition-metal catalyzed alkene functionalizations. The nature of the metal and the ligand should allow controlling regiochemistry as well as stereoselectivity of such transformations. In addition, the same proaromatic reagents will also be applied to radical-type transfer hydrofunctionalization reactions.