Effect of phosphorylation on the archaellum regulatory protein network (P24*)

古生菌利用古生菌来游泳，古生菌是一种通过IV型菌毛机制组装的运动结构。古生菌的表达是一种高度调控和可逆的蛋白磷酸化结合膜的一组分调控因子，ArnR和ArnR1在古生菌调控信号蛋白网络中起着主要的调控作用。我们想要了解磷酸化如何通过生化、结构和体内方法改变古细胞调控网络中的相互作用。

Archaea use the archaellum, a motility structure that is assembled via a type IV pili mechanism, to swim. Expression of the archaellum is highly regulated and reversible protein phosphorylation of the membrane bound one component regulators ArnR and ArnR1 plays a major role in the modulation of the archaellum regulatory signaling protein network. We want to understand how phosphorylation alters the interactions in the archaellum regulatory network using biochemical, structural and in vivo approaches.