Dissecting the regulatory mechanisms of alternative polyadenylation and nuclear retention of mRNAs by SR proteins (B13)

SR蛋白是中心rna结合蛋白，伴随mrna从细胞核转录到细胞质翻译的整个过程。因此，它们具有将随后的RNA加工步骤与核监视联系起来的潜力。然而，除了剪接之外，它们的功能还很少被研究。在这里，我们将阐明SR蛋白在选择性聚腺苷化和调节RNA输出中的作用的分子机制。我们将在神经元分化的背景下研究这些调节功能的生理后果。

SR proteins are central RNA-binding proteins that accompany mRNAs throughout their journey from transcription in the nucleus to translation in the cytoplasm. They thereby hold the potential to link subsequent RNA processing steps for nuclear surveillance. However, their functions beyond splicing remain poorly studied. Here, we will elucidate the molecular mechanisms underlying the roles of SR proteins in alternative polyadenylation and regulated RNA export. We will study the physiological consequences of these regulatory functions in the context of neuronal differentiation.