Dissociation of a Tetrameric Enzyme with Interface-Targeted Peptides

随着抗生素耐药性的上升，迫切需要开发新的抗生素，同样迫切需要确定新的抗生素靶点。其中一个目标是二氢二吡啶合酶（DHDPS），它催化细菌中赖氨酸和细胞壁生物合成的关键步骤。本课题旨在开发针对DHDPS的新药，有效、快速地治疗包括胃肠炎在内的细菌感染。最近的统计数据显示，每年有500多万澳大利亚人患有胃肠炎，土著儿童因这种感染住院的人数比非土著儿童高出近7倍。因此，这项研究有可能确保数百万澳大利亚人拥有一个更健康的未来。

With antibiotic resistance on the rise, there is an urgent need to develop new antibiotics and an equally urgent need to characterise new antibiotic targets. One such target is dihydrodipicolinate synthase (DHDPS) which catalyses the critical step in lysine and cell wall biosynthesis in bacteria. This proposal aims to generate new drugs targeting DHDPS for effective and rapid treatment of bacterial infections, including gastroenteritis. Recent statistics show that over 5 million Australians suffer from gastroenteritis each year and hospitalisation for this infection is nearly seven times higher for indigenous than non-indigenous children. Accordingly, this research has the potential to assure a healthier future for millions of Australians.