Dermal Peptide Delivery

由于多肽的亲水性和相对于小分子的高分子量，它们大多无法穿透人体皮肤的生物物理屏障——角质层。因此，到目前为止，它们还没有在皮肤药学和治疗中使用。这个项目的目的是研究如何渗透肽剂进入皮肤可以增强，以便能够在局部治疗中使用这些药物。四肽将在稳定性测试后用作模型肽。关于增强穿透性，我们在完整和受损皮肤上进行了以下测试：与胶体载体系统的结合渗透增强分子的应用。该项目将通过皮肤科医生、药剂师和化学家的跨学科合作来实现。该项目的结果将为进一步的皮肤药物研究奠定基础，目的是利用具有高分子质量的寡肽和蛋白质进行特定皮肤疾病的透皮治疗。

Because of their hydrophilic properties and high molecular weight compared to small molecules Peptides are mostly unable to penetrate the stratum corneum, the biophysicalic barrier of the human skin. Therefore, they have not been used in dermato-pharmacy and therapy so far. Aim of this project is to investigate how penetration of peptide agents into the skin can be enhanced, in order to be able to use these agents in topical therapy. Tetrapeptides will be used as model peptides after tests of their stability. The followings tests are performed on intact as well as damaged skin regarding penetration enhancing:1. Incorporation into colloidal carrier systems2. Application of penetration enhancer molecules.This project will be realized by interdisciplinary cooperation in between dermatologists, pharmacists and chemists. The results of this project will be the basis for further dermato-pharmaceutical studies with the objective to use oligopeptides and proteins with high molecular mass in transdermal therapy for specific skin disorders.