Structural brain imaging correlates of schizophrenia symptomatology and their genetic background

精神分裂症患者认知和临床症状的相当大的差异性可能反映了各种病因的影响，并限制了对潜在病理过程的探索。调查更明显的疾病症状有助于研究精神分裂症的脑部相关性和遗传背景。本项目的研究目标是调查a)阴性和阳性症状学-精神分裂症的核心症状-的结构相关性，以及b)症状类别和相关大脑结构背后的遗传学。它计划使用来自通过荟萃分析(Enigma)联盟的神经成像遗传学(Enigma)联盟的人口统计、临床、遗传和结构成像数据。该联盟拥有超过15个国际站点，包括2000多名精神分裂症患者和更多的健康对照的数据。结合先进的成像、基因组范围和元分析方法，将允许以无假设和标准化的方式调查这些关系，有助于深入了解这种疾病的更具体和更具因果的神经生物学机制。

The considerable variability of cognitive and clinical symptoms across patients with schizophrenia likely reflects the impact of various etiological factors and limits the search for underlying pathological processes. Investigating more distinct symptoms of the disease could help to study the brain-based correlates and the genetic background of schizophrenia.The research objectives of this project are to investigate a) the structural correlates of negative and positive symptomatology - core symptoms of schizophrenia - and b) the genetics behind both symptom classes and related brain structures. It is planned to use demographic, clinical, genetic and structural imaging data from the Neuro Imaging Genetics Through Meta-Analysis (ENIGMA) consortium. With over 15 international sites, this consortium includes data of over 2000 patients with schizophrenia and an even larger number of healthy controls.Combining advanced imaging, genome-wide and meta-analytical approaches will allow for the investigation of these relationships in a hypothesis-free and standardized manner helping to gain insight into more specific and causal neurobiological mechanisms of the disorder.