The role of learning, stress and underlying brain circuits involving prefrontal-limbic interactions in the development of chronic back pain (B03)

这个项目将研究食欲和厌恶情绪学习以及奖励处理和相关的大脑回路在慢性背痛的发展。精神障碍与压力和共病的关系将是一个特别的焦点。在一种新的超扫描方法中，社会强化的作用将通过同时监测疼痛相关的大脑激活以及对患者和重要他人日常疼痛相关的社会互动进行微观分析来研究。通过采用经颅磁刺激和真实的实时功能磁共振成像反馈，将对识别的脑回路进行机械检查，这也具有治疗功能。

This project will examine appetitive and aversive emotional learning as well as reward processing and associated brain circuits in the development of chronic back pain. The relationship to stress and comorbidity with mental disorder will be a special focus. In a novel hyper-scanning approach, the role of social reinforcement will be examined by simultaneous monitoring of the pain-related brain activation as well as a microanalysis of daily pain-related social interactions in patients and significant others. The identified brain circuits will be mechanistically examined by employing transcranial magnetic stimulation and real time functional magnetic resonance imaging feedback, which also serves therapeutic functions.