Regulation of angiogenesis by targeting the melanoma microenvironment and its immune cells (B10#)

我们确定了如何高效的抗肿瘤免疫反应可以启动特异性激活黑色素瘤驻留肥大细胞（MC）。肿瘤浸润效应T细胞（TIL）被MC衍生的CXCL10募集，初步数据表明，血管生成的抑制有效地参与了这种有效的肿瘤免疫控制。因此，作为肿瘤免疫治疗的一部分的血管生成的抑制将在机制上进行研究，重点是MC和TIL。重要的是，通过支持CRC肿瘤控制，将对小鼠和人类中的T细胞募集和血管生成抑制进行成像，从而允许进行适当调整以进一步优化黑素瘤的治疗。

We identified how highly efficient anti-tumor immune responses can be initiated by specific activation of melanoma-resident mast cells (MC). Tumor-infiltrating effector T cells (TILs) were recruited by MC-derived CXCL10 and preliminary data indicate that inhibition of angiogenesis is potently participating in this efficient tumor immune control. Thus, the inhibition of angiogenesis as part of tumor immune therapy will be mechanistically investigated with a focus on MC and TILs. Importantly, by support of the CRC tumor control, T-cell recruitment, and inhibition of angiogenesis in mice and humans will be imaged allowing the appropriate adjustments to further optimize treatment of melanoma.