Fibers, non-woven meshes, and hydrogels based on spider silk and magnetic nanoparticles for bio-inspired shaping and filtering systems

该项目的目标是为基于磁性纳米颗粒和蜘蛛丝蛋白杂交体的新型生物灵感成形系统建立科学和技术基础。所采用的基因工程和重组生产的蜘蛛丝蛋白可以使用特定部位的化学方法与特定的磁性纳米颗粒共价交联，或者它们可以与各种磁性纳米颗粒混合。基于潜在的蜘蛛丝蛋白的自然行为，以可控的方式组装和加工成纳米、微观和宏观的纤维结构是可能的。在与磁性纳米颗粒偶联或共混后，将分析所得到的蜘蛛丝纤维、纤维网和纤维水凝胶的磁响应性、成形能力以及它们作为具有可控孔径的典型过滤系统的适用性。

The objective of this project is to establish a scientific and technological basis for novel bio-inspired shaping systems based on hybrids made of magnetic nanoparticles and spider silk proteins. The employed engineered and recombinantly produced spider silk proteins can be covalently cross-linked with specific magnetic nanoparticles using site-specific chemistry, or they can be blended with a variety of magnetic nano particles. Based on the natural behavior of the underlying spider silk proteins, assembly and processing into nano-, micro- and macroscopic fibrillar structures is possible in a controllable manner. Upon coupling or blending with magnetic nanoparticles, the resulting spider silk fibers, fiber meshes, and fibrillar hydrogels will be analyzed concerning their magnetic responsivity, shaping abilities and concerning their applicability exemplary as filter systems with controllable pore sizes.