Physiological Regulation of Chronic Tinnitus

慢性耳鸣与中枢听觉系统抑制的减少共同变化。该项目研究了一种新的康复策略，该策略使用听觉系统中的局部神经元抑制训练和局部α-EEG-神经反馈：3个可比较的随机分组，每组30名慢性耳鸣患者接受（1）局部听觉α节律的神经反馈，同时接受α-在实验组（EG）中，阻断大脑的躯体感觉和视觉投射区域以恢复听觉系统中的生理抑制，（2）对照组（CG）接受与EG相同的训练，但在听觉皮层α和反馈之间没有关联（偶然性）;（3）第三组接受耳鸣的认知行为疗法（CBT）。我们期望EG显示耳鸣的神经生理学和行为和感知稳定减少，并且听觉系统的局部神经元抑制（α）和皮质重组反映康复训练的行为改善。

Chronic tinnitus co-varies with a decrease of inhibition of the central auditory system. This project investigates a new rehabilitation strategy using training of local neuronal inhibition in the auditory system with local alpha-EEG-neurofeedback: 3 comparable randomized groups of 30 patients each suffering from chronic tinnitus receive (1) Neurofeedback of local auditory alpha-rhythm with simultaneous alpha-blockade in the somatosensory and visual projection areas of the brain in order to revive physiological inhibition in the auditory system in the experimental group (EG), (2) receive identical training as the EG but without association (contingency) between auditory cortex alpha and feedback in the control group (CG) and (3) receive cognitive behavior therapy (CBT) of the tinnitus in the third group. We expect that the EG shows a neurophysiological and behavioral and perceptual stable reduction of tinnitus and that local neuronal inhibition (alpha) and cortical reorganization of the auditory system reflect the behavioral improvement of the rehabilitation training.