Analysis of the basics and modelling of the Flow-Field-Thermal-Gradient-Gas-Chromatography

该研究提案的目的是分析具有纵向负温度梯度的新气相色谱（GC）方法的基础。在这样的梯度下，色谱带被永久聚焦，因为峰前被减速，峰尾被加速。这种聚焦效应补偿了扩散带的加宽。当柱的温度水平同时提高时，柱上的物质在不同的温度下被捕获，该温度由色谱速度和温度沿着柱的速度的等效性确定。因此，在梯度场中，物质以恒定的温度沿着柱移动，而没有经典GC模式中的增加。在申请人先前的研究计划和以下痕量气体分析研究的背景下，已经开发了热梯度GC的技术上简单的实现。这是第一次，它现在可以研究的基础上的热梯度气相色谱（TG-GC）与这个实验装置。第一次测量结果是相当有希望的。测量时间低于60秒的高色谱分辨率已获得。与传统的气相色谱相比，迄今为止只有有限的经验，没有系统的评价TG-GC。该概念保证了大大改进的快速分离，这有利于例如气体传感器系统、离子迁移谱法以及与质谱法的组合。由于降低了分离温度，热不稳定组分，如一些芳香化合物、生物底物和高能材料也可以通过TG-GC分离和分析。

The aim of the research proposal is the analysis of the basics of a new gas chromatographic (GC) method with a longitudinal negative temperature gradient. With such a gradient the chromatographic bands are permanently focussed because the peak fronts are decelerated and the peak tails are accelerated, respectively. This focussing effect compensates the diffusive band broadening. As the temperature level of the column is enhanced simultaneously the substances on the column are trapped at a distinct temperature that is determined by the equivalence of the chromatographic velocity and the velocity of the temperature along the column. In the gradient field the substances therefore move along the column with a constant temperature without the increase in the classical GC mode. In the context of the previous research program of the applicant and following studies of trace gas analytics a technically simple realisation of the thermal gradient GC has been developed. For the first time it is now possible to study the basics of the thermal gradient gas chromatography (TG-GC) with this experimental setup. The first measurement results are quite promising. With measurement times below 60 s high chromatographic resolutions have been obtained. In contrast to the classical GC up to now only limited experiences and no systematic evaluations of the TG-GC are available. The concept promises a largely improved fast separation which is favourable for e.g. gas sensor systems, ion mobility spectrometry and in combination with mass spectrometry. Due to the reduced separation temperatures also thermally labile components such as some aroma compounds, biological substrates and also energetic materials can be separated and analysed by TG-GC.