Diffusion in Multi-Component Polymeric Systems: Diffusion of Non-Volatile Species

聚合物体系中的分子扩散在许多高质量产品的生产中起着重要作用。例子包括用于lcd面板的箔片、透皮贴片或医学测试条和用于液体分离的膜。扩散行为对聚合物体系的物理和化学性能有重要影响，包括机械和光学性能、润湿行为或药物释放速率，即产品质量。在这个项目中进行的研究是对含有挥发性物质（溶剂）和非挥发性物质（这里称为非挥发性物质）的多种组分的聚合物系统中的扩散进行全面研究，例如lcd面板箔中的软化剂或诊断中的添加剂或透皮贴剂中的药物。研究的重点将是（多个）非挥发性物质在聚合物体系中的扩散。将应用的实验技术是逆微拉曼光谱（IMRS），该技术已由卡尔斯鲁厄的PI开发。多组分混合物中的化学成分可以就地检测，无需接触。目前，在该研究领域中，聚合物薄膜中的浓度梯度测量具有较高的时间、空间和定量分辨率。为了在控制边界条件下精确测量多组分扩散，我们将建造一个新的扩展实验装置。实验结果将用于评估和发展多组分质量输运的数学模型。

Molecular diffusion in polymeric systems plays an important role in the production of many high-quality products. Examples include foils for LCD-panels, transdermal patches or medical test strips and membranes for liquid separations. The diffusion behavior has an important impact on the physical and chemical properties, including mechanical and optical properties, wetting behavior or drug release rates i.e. the product quality of the polymeric system. The research to be conducted in this project is a comprehensive study of diffusion in polymeric systems containing multiple components of volatile species (solvents) and non-volatile species called non-volatiles here such as softeners in LCD-panel-foils or additives in diagnostics or drugs in transdermal patches. The focus of the research will be on diffusion of (multiple) non-volatile species in polymeric systems. The experimental technique, which will be applied, is the Inverse-Micro-Raman-Spectroscopy (IMRS), which has been developed by the PI of this proposal in Karlsruhe. Chemical compositions in multi-component mixtures can be detected locally and contact-free. Currently, concentration gradients in thin polymeric films can be measured with a best level of temporal, spatial and quantitative resolution in this research field. An extended and new experimental apparatus will be constructed especially for precise measurement of multi-component diffusion under controlled boundary conditions. Experimental results will be used to evaluate and develop mathematical models for multicomponent mass transport.