Depression and subgroups - analysis of vascular MRI parameters in different subgroups of depression

影响抑郁症发展的生物因素具有高度异质性。迄今为止，大多数研究集中在血管危险因素与晚发性抑郁症的关系，而没有考虑抑郁症的不同亚组。晚发性抑郁症和心血管危险因素之间的双向联系是已知的，血管性抑郁症的假说成立。抑郁症亚型的概念假设每种亚型都可能以特定的方式与发展CVD的风险有关。本项目的目的是调查和分析不同亚组抑郁症患者的脑血管变化，并验证血管性抑郁的假设是否也适用于抑郁症亚组。血管危险因素对抑郁症亚组影响的证据可能会导致治疗的显着优化。

There is a high heterogeneity of biological factors that influence the development of depression. Up to now most of the studies focused on the relationship between vascular risk factors and late-onset - depression without considering the different subgroups of depression. The bi-directional link between late-onset - depression and cardiovascular risk factors is known and the hypothesis of vascular depression established. The concept of depression subtypes postulates that each may relate to the risk of developing CVD in a specific way. The aim of the current project is to investigate and analyse vascular brain changes in patients with depression in different subgroups and to validate if the hypothesis of the vascular depression can also be applied on depression subgroups. Evidence for the influence of vascular risk factors on subgroups of depression could lead to a significant optimization of therapy.