Regulation of virus-specific CD4 T helper cell responses in viral hepatitis (04)

CD4 T辅助细胞是调节抗病毒免疫反应的核心角色。它们对于维持细胞毒性CD8 T细胞反应和产生抗体的B细胞的出现尤其重要。CD4 T辅助细胞室的不同亚群参与这些功能。本项目旨在确定在急性和慢性病毒性肝炎的设置CD4 T辅助室的组成。这些观察结果可以为成功的CD4 T细胞反应提供蓝图，从而为疫苗设计提供信息。

CD4 T helper cells are central players in the regulation of the antiviral immune response. They are particularly important for the maintenance of cytotoxic CD8 T cell responses and the emergence of antibody-producing B cells. Distinct subpopulations of the CD4 T helper compartment are involved in these functions. This project aims to define the composition of the CD4 T helper compartment in the setting of acute and chronic viral hepatitis. These observations could provide a blueprint of successful CD4 T cell responses that could inform vaccine design.