Novel principles in bacterial central carbon metabolism: Linking environmental signals and metabolic responses in alphaproteobacteria (D02*)

为了实现最佳生长，生物需要在能源节约和生物质形成之间紧密平衡碳的分布，以应对不断变化的环境。到目前为止，这一过程主要在大肠杆菌中进行研究，但越来越多的证据表明，其他细菌遵循不同的策略。在这里，我们将描述环境丰富的甲型变形杆菌中中心碳代谢的代谢和调节多样性。我们将确定控制碳同化的环境因素和信号，并研究阿尔法变形杆菌中心碳代谢对外界扰动的动态响应。

To achieve optimal growth, organisms need to tightly balance the distribution of carbon between energy conservation and biomass formation in response to a changing environment. So far this process has been mainly studied in Escherichia coli, but evidence accumulated that other bacteria follow different strategies. Here, we will characterize the metabolic and regulatory diversity of central carbon metabolism in the environmentally abundant group of alphaproteobacteria. We will identify environmental factors and signals that control carbon assimilation and study the dynamic res¬ponse of central carbon metabolism of Alphaproteobacteria upon external perturbation.