Regulation of motility by the stringent response in B. subtilis (E06*)

报警激素(p)ppGpp在细菌的环境信号响应（严格响应）中起着至关重要的作用。双功能的RelA/SpoT蛋白在细菌中是保守的，并介导它们的合成和降解。在厚壁菌门中，存在两个额外的小警报器合成酶（SAS1/2）。虽然它们的生化/结构特征被很好地理解，但它们在细胞对环境信号反应中的作用滞后。我们将定义SAS1/SAS2在枯草芽孢杆菌细胞信号网络中的作用，并揭示它们的(p)ppGpp产物在运动调节和锌胁迫反应中的作用。

The alarmones (p)ppGpp play crucial roles in the environmental signal response of bacteria (stringent response). The bifunctional RelA/SpoT proteins are conserved in bacteria and mediate their synthesis and degradation. In the Firmicutes, two additional small alarmone synthetases (SAS1/2) are present. While their biochemical/structural features are well understood, their role within the cellular response to environmental signals lags behind. We will define the roles of SAS1/SAS2 within the cellular signaling network of B. subtilis and unravel the role of their (p)ppGpp product for motility regulation and response to zinc stress.