Mechanisms of sensing and response to environmental cues by fungal cell wall components (E09*)

在这个项目中，我们小组的重点是真菌细胞壁及其成分的结构生物学。在研究了真菌粘附素的结构库和特异性之后，我们现在将结合生化、结构和功能方法来研究细胞壁锚定蛋白，这对细胞壁交联、完整性和重塑至关重要。通过加深我们对真菌细胞壁复杂超微结构的了解，我们将为杀菌剂的开发和优化提供结构线索。

In this project our group focuses on the structural biology of fungal cell walls and their components. After having studied the structural repertoire and specificity of fungal adhesins we will now combine biochemical, structural and functional approaches for studying cell wall-anchored proteins, which are crucial for cell wall cross-linking, integrity and remodelling. By advancing our understanding of the complex ultrastructure of fungal cell walls we will provide structural cues for the development and optimization of fungicides.