Mobile Brain/Body Imaging of Spatial Navigation

这项建议的目标是调查的皮质动力学，支持空间定向在积极的人类运动在空间反映整合的独特的信息，从视觉，前庭，和动觉系统。这一总体目标将有助于发展空间导航理论，以及不同的感官如何有助于空间定向。此外，所提出的实验旨在模拟大脑动力学伴随视觉和前庭信息的物理旋转和空间平移，以及这些如何有助于空间更新。最后，调查起源于或附近的压后复合体（RSC），大脑结构，是中央的空间定向的脑动力学，将有助于确定潜在的不同的计算功能，这个结构。为此，我们将在一系列实验中比较主动物理空间定向和视觉流定向。为了在移动的空间定向脑电图（EEG）期间记录人脑动力学，将同步全身运动捕获和头戴式虚拟现实。为了对记录的活动进行成像，将使用数据驱动的分析方法来研究人脑动力学，身体运动和认知过程之间的相互依赖关系。在过去的十年中，记录技术使得能够在标准实验室设置之外记录移动的参与者的EEG活动。开发了数据驱动的分析方法，可以将大脑和非大脑活动分开。尽管有这些发展，但研究人类认知的标准方法要求参与者避免移动，并专注于传感器水平的分析。为了进一步了解大脑动态，伴随着自然的认知过程，是紧密的，并利用我们的身体结构，我们建议在积极移动的参与者的空间定向过程中的大脑动态图像。脑动力学成像必须提供特定皮质结构何时表现出与认知和行为方面相关的系统性活动变化的信息。电生理学数据提供了必要的时间分辨率，以提供对信息处理时间过程的精确见解。伴随空间定向整合运动相关的独特性反馈的脑动力学是未知的。该建议旨在通过使用移动的脑/体成像来克服空间定向的脑成像研究的现有局限性。这将得出有关大脑如何表示独特信息、这些信息如何用于空间定向以及独特信息处理的大脑动力学如何影响空间任务中的个体差异的结论。

The goal of this proposal is to investigate the cortical dynamics that support spatial orienting during active human movement in space reflecting the integration of idiothetic information from the visual, the vestibular, and the kinesthetic system. This overall objective shall help to develop theories of spatial navigation and how different senses contribute to spatial orienting. Furthermore, the proposed experiments aim at modeling the brain dynamics accompanying visual and vestibular information on physical rotation and translation in space, and how these contribute to spatial updating. Finally, investigating the brain dynamics originating in or near the retrosplenial complex (RSC), a brain structure that is central to spatial orienting, will contribute to identifying potential different computational functions of this structure. To this end, we will compare active physical spatial orienting with visual flow orienting in a series of experiments. To record the human brain dynamics during mobile spatial orienting electroencephalography (EEG), full-body motion capture, and head mounted virtual reality will be synchronized. To image the recorded activity, data-driven analyses approaches will be used to investigate the interdependencies between human brain dynamics, physical movement, and cognitive processes. The last decade has brought recording technologies that allow a recording of EEG activity in mobile participants outside standard laboratory settings. Data-driven analyses approaches were developed that allow for separating brain and non-brain activities. Despite these developments, the standard approach to investigating human cognition requires participants to avoid movement and focuses on analyses at the sensor level. To further our understanding of the brain dynamics that accompany natural cognitive processes that are tight to and make use of our physical structure, we propose to image the brain dynamics during spatial orienting in actively moving participants. Imaging of brain dynamics has to provide information about when specific cortical structures demonstrate systematic changes in activity that can be linked to aspects of cognition and behavior. Electrophysiological data provide the temporal resolution necessary to deliver precise insights into the time course of information processing. The brain dynamics accompanying spatial orienting integrating movement-related idiothetic feedback are unknown. This proposal aims to overcome the existing limitations to brain imaging studies of spatial orienting by using mobile brain/body imaging. This will allow conclusions as to how the brain represents idiothetic information, how this information is used for spatial orienting, and how the brain dynamics of idiothetic information processing contribute to individual differences in spatial tasks.