Effects of repetitive magnetic stimulation on synaptic plasticity deficits in hepatic encephalopathy - cellular and molecular mechanisms (B11#)

肝性脑病(HE)与神经元表达突触可塑性的能力改变有关。本项目评估重复经颅磁刺激(RTMS)对小鼠器官型脑片培养中内稳态和关联性突触可塑性的神经胶质和神经元介质的HE相关改变的影响。这些结果将为HE相关突触可塑性改变的细胞和分子机制提供新的重要见解，并可能为rTMS在HE患者的诊断和治疗中的应用铺平道路。

Hepatic Encephalopathy (HE) is associated with alterations in the ability of neurons to express synaptic plasticity. This project evaluates the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on HE-associated alterations of glial and neuronal mediators of homeostatic and associative synaptic plasticity in mouse organotypic slice cultures. The results will provide new important insights on the cellular and molecular mechanisms of HE-associated alterations in synaptic plasticity and may pave the way toward a diagnostic and therapeutic use of rTMS in HE-patients.