The photopic negative response as a biomarker for functional integrity of the optic nerve

在项目的第一阶段，已经使用不同的技术研究了明视负响应(PhNR)。这些技术旨在优化PhNR的信噪比，并阐明导致PhNR的通路中的锥体驱动信号。这些数据已被用于对正常受试者和青光眼患者进行实验。结果表明，在最佳刺激条件下，PhNR是一种潜在的青光眼生物标志物。此外，Erlangen实验室和Freiburg实验室已经使用了刺激范例，以便能够比较两个实验室获得的结果。这项工作的目标是全面描述ERG成分和刺激条件，这些成分和刺激条件是诊断和监测青光眼的最佳条件。将在正常受试者和使用这些条件的青光眼患者之间进行全面的比较研究。计划与相同个体的ERG模式进行比较。将对在弗莱堡和埃尔兰根进行的测量结果进行比较。在所要求的一年中的另一个工作目标。最后，将电生理数据与来自相同个体的结构数据(OCT、HRT；GDX)进行比较。

In the first period of the project, the photopic negative response (PhNR) has been studied using different techniques. These techniques aimed at optimizing the signal-to-noise ratio of the PhNR and at elucidating cone driven signals in the pathways leading to a PhNR. The data have been used to perform experiments with normal subjects and glaucoma patients. The results indicate that the PhNR is a potential biomarker for glaucoma when using optimal stimulus conditions. In addition, a stimulus paradigm has been used in the lab Erlangen and in Freiburg to be able to compare the results obtained in the two labs.The goal of the work will be a full description of the ERG components and the stimulus conditions that are optimal for diagnosis and monitoring of glaucoma. A full comparative study between normal subjects and glaucoma patients using these conditions will be performed. A comparison with the pattern ERG in identical individuals is planned. A comparison of the outcome of the measurements performed in Freiburg and in Erlangen will be performed. An additional goal of work in the requested year. Finally, the electrophysiological data will be compared with structural data (OCT, HRT; GDx) from the same individuals.