INTEGRATED ANALYSIS OF STEM CELL FUNCTION IN PLANT GROWTH AND DEVELOPMENT (ERA-PG 059)

干细胞对植物的生长和发育至关重要，是所有农业和林业的最终起源。尽管已经确定了干细胞建立和维持所需的一些关键基因，但我们缺乏关于控制不同干细胞群体的细胞分化和细胞周期的网络的信息，缺乏这些机制如何决定不同干细胞群体的共同和特定行为，以及它们如何将干细胞活动与不断变化的环境条件相结合。这项建议整合了世界领先的实验室的工作，这些实验室对茎、根和维管分生组织的干细胞种群、细胞周期控制、生长建模和图像分析进行关键研究。欧洲在植物干细胞研究和细胞分裂控制方面处于全球领先地位，这项提议将整合涉及的不同实验室的研究，创造新的协同效应和可观的附加值。结合基因组学、反向遗传学、智能遗传筛选和新型细胞生物学的新工具和策略将被用来解决由转录因子指定干细胞区域如何转化为分裂和分化的细胞机制这一关键问题，并确定不同干细胞群体中共同和不同的调控网络。

Stem cells are essential to the growth and development of plants and provide the ultimate origin of all agriculture and forestry. Although some key genes required for the establishment and maintenance of stem cells are identified, we lack information on the networks governing cell differentiation and cell cycle of different stem cell populations, on how these mechanisms determine common and specific behaviors of the different stem cell groups and how they integrate stem cell activity with changing environmental conditions. This proposal integrates the work of world-leading labs that perform key research on stem cell populations of the shoot, root and vascular meristems, cell cycle control, growth modeling and image analysis. Europe has a global lead in plant stem cell research and cell division control, and this proposal will integrate the research of the different labs involved, creating new synergies and substantial added value. New tools and strategies combining genomics, reverse genetics, smart genetic screens, and novel cell biology will be exploited to address the key issue of how specification of stem cell regions by transcription factors translates to cellular mechanisms for division and differentiation and identify common and distinct regulatory networks in different stem cell populations.