Rolle der alimentären und genetischen Modulation des Fettsäurestatus für das Erkrankungsrisiko für Typ 2 Diabetes mellitus

脂肪酸生物标志物提供了膳食暴露的综合测量，并允许检测脂肪酸代谢的变化。在EPIC-Potsdam研究中，红细胞膜的脂肪酸谱与2型糖尿病的风险以及CRP和脂联素的血浆水平相关。这些发现和对FADS 1-FADS 2遗传变异的分析突出了参与脂肪酸代谢的去饱和酶在糖尿病发病机制中的潜在作用。我们的目标是阐明潜在的途径之间的关联脂肪酸概况和糖尿病风险评估糖尿病前期标志物以及代谢组学概况使用效果分解方法和路径分析。此外，我们将确定与脂肪酸谱相关的食物模式，并确定这些模式是否与糖尿病风险相关。此外，我们的目的是评估脂肪酸标志物是否是德国糖尿病风险评分（EPIC-Potsdam开发的糖尿病预测模型）的信息扩展。

Fatty acid biomarkers provide an integrated measure of dietary exposure and allow detecting alterations in fatty acid metabolism. Fatty acid profiles of erythrocyte membranes were related to risk of type 2 diabetes and plasma levels of CRP and adiponectin in the EPIC-Potsdam study. These findings and analyses on genetic variants in FADS1-FADS2 highlight a potential role of desaturases involved in fatty acid metabolism in the pathogenesis of diabetes. We aim to elucidate potential pathways underlying the association between fatty acid profiles and diabetes risk by evaluating prediabetic markers as well as metabolomic profiles using effect decomposition methodology and path analysis. In addition, we will identify food patterns related to fatty acid profiles and determine whether these patterns are related to diabetes risk. We furthermore aim to evaluate whether fatty acid markers are informative extensions to the German Diabetes Risk Score, a diabetes prediction model developed in EPIC-Potsdam.