Extended fetal monitoring by systematic analysis of fetal autonomic cardiovascular regulation

临床上可用于评估胎儿健康和发育状况的程序至今仍太不精确，仅部分适用于预后应用。在早期妊娠阶段，它们有时根本不适用。该项目的目的是通过对胎儿心血管调节的分析来表征早期妊娠(怀孕20-28周)的胎儿状况。为此，创新的系统分析方法被用来刻画胎儿心率变异性随内外影响因素的动态变化，即进行基于上下文的胎儿变异性分析。由此获得的信息将在今后用于预防性治疗，尤其是用于确定发生并发症的最佳时间。在临床研究的背景下，该项目将首次利用基于背景的变异性分析的生物医学方法证明：(1)可以显示胎儿自主调节的特征纵向发展；(2)对这一发展的监测是改善风险妊娠供应的基础，这可以决定性地影响早期妊娠干预的决定。

The clinically available procedures for assessing the fetal health and development status are still too imprecise today and are only partially suitable for prognostic applications. In the early gestational age, they are sometimes not applicable at all. The aim of the project is to characterize the fetal condition during the early gestational age (20 - 28 weeks of pregnancy) by the analysis of fetal cardiovascular regulation. To this end, the innovative system-analytic approach is used to characterize the dynamics of fetal heart rate variability as a function of internal and external factors of influence, that is, to conduct a context-based fetal variability analysis. The information obtained from this is to be used in the future for preventive treatment, not least for the determination of the optimal time of onset of complications. In the context of a clinical study, the project will demonstrate for the first time, using biomedical methods of the context-based variability analysis, that (1) a characteristic longitudinal development of the fetal autonomous regulation can be shown and (2) the monitoring of this development is the basis for an improved supply of risk pregnancies, which can decisively influence the decision on interventions in the early gestational age.