NMR and biophysical characterization of structure and dynamics of µ-proteins and their complexes.

小蛋白质由小开放阅读框（sORF）编码，并且由大约60个氨基酸组成。小分子蛋白质与多种细胞功能有关，包括细胞分裂、运输和激酶调节、形态发生和应激反应。在我们的项目中，我们将通过核磁共振（NMR）光谱研究小蛋白及其复合物的结构和动力学。我们将继续在SPP 2002中与十多个不同的团体进行富有成效的合作。除了使用在第一个资助期成功建立的工作流程来表征单个小蛋白质外，我们还将重点研究小蛋白质与（较大）蛋白质、DNA、RNA或脂质的复合物。

Small proteins are encoded by small open reading frames (sORFs) and consist of around 60 amino acids. Diverse cellular functions have been linked to small proteins including cell division, transport and kinase regulation, morphogenesis and stress response. In our project, we will investigate the structure and dynamics of small proteins and their complexes by nuclear magnetic resonance (NMR) spectroscopy. We will continue our fruitful collaborations within SPP2002 with more than ten different groups. Beside characterizing the invidual small proteins using a workflow successfully established in the first funding period, we will also put focus on investigating complexes of small protein with (larger) proteins, DNA, RNA or lipids.