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Nanoseond Ultra-Rapid Freeze Quenching for Time-resolved Structural Biology

Nanoseond Ultra-Rapid Freeze Quenching for Time-resolved Structural Biology
用于时间分辨结构生物学的纳秒超快速冷冻淬火
批准号:
451906961
负责人:
Professor Dr. Harald Schwalbe
金额:
$0.0万
依托单位国家:
德国
项目类别:
New Instrumentation for Research
财政年份:
--
资助国家:
德国
项目状态:
未结题
起止时间:

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中文摘要
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英文摘要
The application aims to develop instrumentation for the time-resolved studies of biochemical processes, yielding 3D molecular movies recorded with atomic resolution in real time. Application targets regular and custom-made equipment for pre-steady-state triggering, sampling, probing and detection, including optical, cryo-sedimentation and ultra-high vacuum systems, UHPLC sample delivery and the computation cluster upgrade. Such instrumentation will be essential for time-resolved structural biology, in particular solid state NMR and cryo-EM.
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Structure, dynamics and kinetics of folding of G-quadruplex nucleic acids
Effects of glycosylation on protein structure, function and dynamics
Dynamic basis of the molecular mechanism of nucleotide secondary messengers-sensing riboswitches by NMR spectroscopy
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  • 批准号:
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  • 项目类别:
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  • 资助金额:
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  • 项目类别:
    面上项目
  • 资助金额:
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